Ko W-C, Chiang S-R, Yan J-J, Chuang Y-C
Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan.
Clin Microbiol Infect. 2005 Jul;11(7):553-8. doi: 10.1111/j.1469-0691.2005.01181.x.
Two bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae, Ah-2743 and Kp-129, respectively, were studied for their relative pathogenicity in comparison with Escherichia coli ATCC 25922. Ah-2743 caused significantly higher serum levels of tumour necrosis factor-alpha, interleukin (IL)-1beta or IL-6 in human whole blood, and higher serum IL-1beta and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. In addition, in BALB/c mice infected by intraperitoneal inoculation, Ah-2743 caused a higher fatality rate (80%) than did Kp-129 (0%). With intramuscular inoculation, Ah-2743 caused more rapid and intense local accumulation of inflammatory cells than did Kp-129, and myonecrosis was present only in Ah-2743-infected mice. These data indicate that Ah-2743 is more pathogenic than Kp-129 or E. coli ATCC 25922 for BALB/c mice. The cellular components or extracellular factors associated with increased cytokine induction and pathogenicity of A. hydrophila in mice merit further investigation.
对两株分别为嗜水气单胞菌（Aeromonas hydrophila）和肺炎克雷伯菌（Klebsiella pneumoniae）的血行感染分离株Ah-2743和Kp-129，与大肠埃希菌（Escherichia coli）ATCC 25922相比，研究了它们的相对致病性。与Kp-129和大肠埃希菌ATCC 25922相比，Ah-2743在人全血中引起的肿瘤坏死因子-α、白细胞介素（IL）-1β或IL-6血清水平显著更高，在感染小鼠中引起的血清IL-1β和IL-6水平也更高。此外，在通过腹腔接种感染的BALB/c小鼠中，Ah-2743引起的死亡率（80%）高于Kp-129（0%）。通过肌肉接种，Ah-2743比Kp-129引起更快速和强烈的炎症细胞局部聚集；仅在感染Ah-2743的小鼠中出现了肌坏死。这些数据表明，对于BALB/c小鼠，Ah-2743比Kp-129或大肠埃希菌ATCC 25922更具致病性。与嗜水气单胞菌在小鼠中增加细胞因子诱导和致病性相关的细胞成分或细胞外因子值得进一步研究。
