Schoening T E, Wagner J, Arvand M
Hygiene-Institut, Universität Heidelberg, Heidelberg, Germany.
Clin Microbiol Infect. 2005 Jul;11(7):579-82. doi: 10.1111/j.1469-0691.2005.01180.x.
The antimicrobial susceptibilities of 338 clinical Streptococcus agalactiae isolates from two geographical regions in Germany were determined by agar dilution. All isolates were susceptible to penicillin, cefotaxime and vancomycin. The overall frequencies of erythromycin and clindamycin resistance were 11% and 4.7%, respectively. Determination of resistance phenotypes among the 37 erythromycin-resistant isolates revealed constitutive and inducible MLS(B) resistance in 40.6% and 37.8% of isolates, respectively, and susceptibility to clindamycin in 21.6% of isolates. Only 14.3% of isolates with inducible MLS(B) resistance were identified as clindamycin-resistant by determination of clindamycin MICs. Pulsed-field gel electrophoresis suggested a clonal distribution pattern among the erythromycin-resistant isolates.
采用琼脂稀释法测定了来自德国两个地理区域的338株临床无乳链球菌分离株的抗菌药敏性。所有分离株对青霉素、头孢噻肟和万古霉素敏感。红霉素和克林霉素的总体耐药率分别为11%和4.7%。对37株红霉素耐药分离株的耐药表型进行测定，结果显示分别有40.6%和37.8%的分离株存在组成型和诱导型MLS(B)耐药，21.6%的分离株对克林霉素敏感。通过测定克林霉素MIC，仅14.3%具有诱导型MLS(B)耐药的分离株被鉴定为克林霉素耐药。脉冲场凝胶电泳显示红霉素耐药分离株之间存在克隆分布模式。
