西班牙塞维利亚A、B、C和G群兰氏β溶血性链球菌临床分离株中红霉素和克林霉素耐药性的发生率及机制
Prevalence and mechanisms of erythromycin and clindamycin resistance in clinical isolates of beta-haemolytic streptococci of Lancefield groups A, B, C and G in Seville, Spain.
作者信息
Merino Díaz L, Torres Sánchez M J, Aznar Martín J
机构信息
Servicio de Microbiología, Hospitales Universitarios, Virgen del Rocío, Sevilla, Spain.
出版信息
Clin Microbiol Infect. 2008 Jan;14(1):85-7. doi: 10.1111/j.1469-0691.2007.01881.x. Epub 2007 Nov 22.
Susceptibility to erythromycin and clindamycin was determined in 860 consecutive clinical isolates of beta-haemolytic streptococci belonging to groups A (GAS, n = 134), B (GBS, n = 689), C (GCS, n = 19) and G (GGS, n = 18). Erythromycin resistance was 26.1% in GAS, 15.7% in GBS, 5.3% in GCS and 33.3% in GGS. The highest rate of clindamycin resistance (33.3%) was in GGS, followed by GBS (15.8%), GCS (15.8%) and GAS (5.2%). The M phenotype was predominant in GAS (80%), the constitutive MLS(B) phenotype was predominant in GBS (75%), and all GGS isolates showed the inducible MLS(B) phenotype. The uncommon erythromycin-susceptible and clindamycin-resistant phenotype was found in four GBS and two GCS isolates.
对860株连续分离的A组（A群链球菌，n = 134）、B组（B群链球菌，n = 689）、C组（C群链球菌，n = 19）和G组（G群链球菌，n = 18）β溶血性链球菌临床分离株进行了红霉素和克林霉素敏感性测定。A群链球菌的红霉素耐药率为26.1%，B群链球菌为15.7%，C群链球菌为5.3%，G群链球菌为33.3%。克林霉素耐药率最高的是G群链球菌（33.3%），其次是B群链球菌（15.8%）、C群链球菌（15.8%）和A群链球菌（5.2%）。M表型在A群链球菌中占主导（80%），组成型MLS(B)表型在B群链球菌中占主导（75%），所有G群链球菌分离株均表现为诱导型MLS(B)表型。在4株B群链球菌和2株C群链球菌分离株中发现了罕见的红霉素敏感但克林霉素耐药的表型。
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