Boukamp Petra
Division of Genetics of Skin Carcinogenesis, German Cancer Research Center Heidelberg, Germany.
J Dtsch Dermatol Ges. 2005 Jul;3(7):493-503. doi: 10.1111/j.1610-0387.2005.05037.x.
Skin cancer, the most common cancer world wide, encompasses different tumor entities, the keratinocyte-derived basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) as well as the neuroectodermal malignant melanoma (MM) and the neuroendocrine Merkel cell carcinomas (MCC). While knowledge is significantly increasing about genetic changes contributing to BCCs and MMs, our understanding for the development and progression of SCCs and MCCs is still fragmentary. This review, thus, aims, on the one hand to summarize the present knowledge without claiming completeness and, on the other hand, to provide information on the HaCaT in vitro skin carcinogenesis model that is used to evaluate the functional consequence of genetic aberrations believed to play a role in skin cancer development and progression.
皮肤癌是全球最常见的癌症，涵盖不同的肿瘤类型，包括角质形成细胞来源的基底细胞癌（BCC）、鳞状细胞癌（SCC），以及神经外胚层恶性黑色素瘤（MM）和神经内分泌默克尔细胞癌（MCC）。虽然关于导致基底细胞癌和黑色素瘤的基因变化的知识正在显著增加，但我们对鳞状细胞癌和默克尔细胞癌的发生和发展的理解仍然支离破碎。因此，本综述一方面旨在总结现有知识，但不追求完整性，另一方面提供关于HaCaT体外皮肤致癌模型的信息，该模型用于评估被认为在皮肤癌发生和发展中起作用的基因畸变的功能后果。
