使用遥测技术测试黑素皮质素-II（MT-II）对清醒大鼠的促勃起作用。

The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats.

作者信息

Giuliano F, Rössler A-S, Clément P, Droupy S, Alexandre L, Bernabé J

机构信息

Pelvipharm Laboratories, CNRS, Bat 5, 1 avenue de la Terrasse, 91190, Gif-sur-Yvette, France.

出版信息

Eur Urol. 2005 Jul;48(1):145-51; discussion 151-2. doi: 10.1016/j.eururo.2005.02.023. Epub 2005 Mar 20.

DOI:10.1016/j.eururo.2005.02.023

PMID:15967265

Abstract

OBJECTIVE

The aim of this study is to demonstrate that monitoring, by means of telemetry technology, the increases in intracavernosal pressure (ICP) in freely moving rats using melanotan-II (MT-II) as a proerectile inducer compound is a relevant experimental model to investigate the effects of pharmacological agents on erection.

METHODS

Adult rats were implanted in the corpus cavernosum with a pressure sensor which permitted telemetric monitoring of ICP in freely moving animals following MT-II (0.1, 0.3 and 1 mg/kg) or saline i.v. injections. ICP was also measured after MT-II (0.1, 0.3 or 1 mg/kg) or saline i.v. delivery in anesthetized rats.

RESULTS

In conscious rats, MT-II (1 mg/kg) significantly increased overall erectile activity compared to saline. In anesthetized rats, MT-II-induced increase in overall erectile activity was not statistically significant but displayed a similar pattern.

CONCLUSIONS

The use of telemetry technology allowed to collect quantifiable and reliable data regarding the proerectile activity of MT-II in physiological conditions. The telemetry model appears suitable for investigating the potential inducer proerectile properties of pharmacological agents.

摘要