Masotto C, Caspani G, De Simoni M G, Mengozzi M, Scatturin M, Sironi M, Carenzi A, Ghezzi P
Zambon Research, Bresso, Italy.
Brain Res Bull. 1992 Feb;28(2):161-5. doi: 10.1016/0361-9230(92)90175-w.
Interleukin 1 (IL-1) induces a series of metabolic and endocrine effects. Activation of the hypothalamus-pituitary-adrenal axis, inhibition of food and water intake, elevation of serum interleukin-6 (IL-6) concentration and hypoglycemia are some of the effects induced by IL-1. The purpose of this study was to compare the sensitivity of these effects following central and peripheral administration of IL-1 beta. Different doses of IL-1 beta (0.1-1000 ng/mouse) were centrally (ICV) or peripherally (IP) injected to male mice two hours prior to sacrifice. The ICV administration was more efficacious than the IP injection in elevating serum corticosterone and IL-6 concentrations, whereas no difference was evident in the IL-1 beta-induced hypoglycemia. Central IL-1 beta administration was also more potent than IP injection in inhibiting overnight food and water intake. A dose-dependent effect was evident in all these cases. In summary, our data compare effects elicited by central or peripheral administration of different doses of IL-1 beta. This comparison suggests that the IL-1 beta stimulation of serum corticosterone and IL-6 and inhibition of food and water intake are events more centrally mediated than the IL-1 beta-induced hypoglycemia.
白细胞介素1（IL-1）可引发一系列代谢和内分泌效应。激活下丘脑-垂体-肾上腺轴、抑制食物和水的摄入、提高血清白细胞介素6（IL-6）浓度以及引发低血糖都是IL-1所诱导的部分效应。本研究的目的是比较中枢和外周给予IL-1β后这些效应的敏感性。在处死雄性小鼠前两小时，分别向其脑室内（ICV）或腹腔内（IP）注射不同剂量（0.1 - 1000 ng/小鼠）的IL-1β。在提高血清皮质酮和IL-6浓度方面，脑室内给药比腹腔内注射更有效，而在IL-1β诱导的低血糖方面则无明显差异。中枢给予IL-1β在抑制过夜食物和水的摄入方面也比腹腔内注射更有效。在所有这些情况下均呈现剂量依赖性效应。总之，我们的数据比较了不同剂量的IL-1β中枢或外周给药所引发的效应。这种比较表明，IL-1β对血清皮质酮和IL-6的刺激以及对食物和水摄入的抑制，相比于IL-1β诱导的低血糖，更多是由中枢介导的事件。
