脑室内注射白细胞介素-1可诱导白细胞介素-6在循环中的高表达。
Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.
作者信息
De Simoni M G, Sironi M, De Luigi A, Manfridi A, Mantovani A, Ghezzi P
机构信息
Unit of Neurotransmitter Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
出版信息
J Exp Med. 1990 May 1;171(5):1773-8. doi: 10.1084/jem.171.5.1773.
Abstract
IL-1 is known to have a central role in the induction of acute-phase response, and some of its activities (including induction of some acute-phase proteins) were reported to be mediated by an induction of IL-6. Administration to rats of 200 ng of human rIL-1 by intracerebroventricular injection resulted in a more marked induction of circulating IL-6 than the same dose of IL-1 administered systemically (intravenously or intraperitoneally). Induction of serum IL-6 by centrally administered IL-1 was also observed in hypophysectomized or adrenalectomized rats, suggesting that activation of the hypothalamus-pituitary-adrenal axis is not essential for this effect of IL-1. IL-6 induction was also observed after pretreatment with indomethacin, indicating that the effect was dissociated from the pyrogenic activity of IL-1. Induction of IL-6 by a central action could represent a novel pathway in IL-1-induced acute-phase response.
摘要
众所周知，白细胞介素-1（IL-1）在急性期反应的诱导中起核心作用，据报道其一些活性（包括某些急性期蛋白的诱导）是由白细胞介素-6（IL-6）的诱导介导的。通过脑室内注射给大鼠注射200 ng人重组IL-1，与相同剂量的IL-1全身给药（静脉内或腹膜内）相比，循环IL-6的诱导更为明显。在垂体切除或肾上腺切除的大鼠中也观察到中枢给予IL-1诱导血清IL-6，这表明下丘脑-垂体-肾上腺轴的激活对于IL-1的这种作用并非必不可少。在用吲哚美辛预处理后也观察到IL-6诱导，这表明该作用与IL-1的致热活性无关。中枢作用诱导IL-6可能代表IL-1诱导急性期反应的一条新途径。
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