植物多酚和脂溶性维生素对人恶性培养细胞的细胞毒性作用。
Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells.
作者信息
Ramanathan R, Tan C H, Das N P
机构信息
Department of Biochemistry, Faculty of Medicine, National University of Singapore.
出版信息
Cancer Lett. 1992 Mar 15;62(3):217-24. doi: 10.1016/0304-3835(92)90099-h.
In vitro studies showed that several flavonoids, tannic acid, gallic acid and fat-soluble vitamins inhibited HeLa and Raji lymphoma cell growth. The inhibition trend exhibited by these compounds was similar for both cell lines, and their growth was inhibited dose dependently. Butein, (10 microM), the most potent anti-proliferative agent, exerted 30% growth inhibition and was more effective on HeLa cells. Retinol (100 microM) inhibited cell proliferation completely. Tannic acid was twice as potent as its monomer gallic acid. From structure-activity consideration, the C2,3-double bond of the flavonoid molecule was important for activity. Flavonoid aglycones were more effective than their corresponding glycosides in suppressing cell growth.
体外研究表明，几种黄酮类化合物、鞣酸、没食子酸和脂溶性维生素可抑制HeLa细胞和Raji淋巴瘤细胞的生长。这些化合物对两种细胞系的抑制趋势相似，且其生长呈剂量依赖性抑制。最有效的抗增殖剂（10微摩尔）的布特因产生了30%的生长抑制，且对HeLa细胞更有效。视黄醇（100微摩尔）完全抑制细胞增殖。鞣酸的效力是其单体没食子酸的两倍。从构效关系考虑，黄酮类分子的C2,3-双键对活性很重要。黄酮苷元在抑制细胞生长方面比其相应的糖苷更有效。
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