Ghanbari-Movahed Maryam, Jackson Gloria, Farzaei Mohammad Hosein, Bishayee Anupam
Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.
Front Pharmacol. 2021 Mar 29;12:639840. doi: 10.3389/fphar.2021.639840. eCollection 2021.
Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers. Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria. Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion. The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.
基于天然产物的癌症预防和治疗实体，如黄酮类化合物及其衍生物，已显示出具有显著抑制肿瘤形成和癌细胞生长的能力。柚皮苷是一种存在于多种植物中的天然黄烷酮糖苷，已被证明可调节不同的信号通路并与众多细胞信号分子相互作用，从而产生广泛的药理作用，如改善炎症、氧化应激、代谢综合征、骨骼疾病和癌症。本系统综述的目的是对柚皮苷在各种癌症中的抗肿瘤能力及相关分子靶点进行批判性和全面的评估。通过对科学Direct、PubMed和Scopus进行系统检索以及根据预定义的选择标准进行资格审查来确定研究。本系统综述纳入了87项研究。有强有力的证据表明，单独使用柚皮苷或与其他药物联合使用与抗肿瘤活性之间存在关联。此外，研究表明，与游离柚皮苷相比，柚皮苷-金属络合物具有更强的抗癌作用。已经证明，柚皮苷通过调节涉及细胞增殖、自噬、凋亡、炎症、血管生成、转移和侵袭的几个失调信号级联反应，采用多靶点机制来阻碍癌症的起始、促进和进展。我们的研究结果表明，柚皮苷是癌症预防和治疗的一个有前途的候选物，可能为这种植物化合物未来的临床应用提供大量支持。然而，需要进一步的临床前和临床研究以及药物递送方法来设计柚皮苷的新型制剂，以充分发挥这种黄酮类化合物在癌症预防和干预中的潜力。
