Ishizaka Nobukazu, Ishizaka Yuko, Toda Ei-Ichi, Hashimoto Hideki, Nagai Ryozo, Yamakado Minoru
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Hypertens Res. 2005 Jan;28(1):27-34. doi: 10.1291/hypres.28.27.
The cluster of metabolic and hemodynamic risk factors known as metabolic syndrome is known to be a risk factor for ischemic cardiovascular diseases and stroke. By analyzing the cross-sectional data from 8,144 individuals (age 19-88 years) who underwent general health screening, we have investigated the prevalence of metabolic syndrome, as diagnosed by modified-National Cholesterol Education Program (NCEP) criteria corresponding to the following five categories: triglycerides > or = 150 mg/dl; high density lipoprotein (HDL)-cholesterol < 40 mg/dl in men or < 50 mg/dl in women; fasting plasma glucose > or = 110 mg/dl; systolic/diastolic blood pressure > or = 130/85 mmHg; and body mass index > 25 kg/m2. We found that the prevalence of metabolic syndrome was 19% in men and 7% in women. After adjustment for age, metabolic syndrome was found to be significantly more prevalent in men than in women, with an odds ratio of 3.08 (95% confidence interval [CI] 2.62-3.61, p < 0.0001). Among the five metabolic/hemodynamic risk factor components, hypertension was observed most frequently in individuals with metabolic syndrome, at 85% in men and 87% in women. In addition, multivariate logistic regression analysis adjusted for age, sex, serum total cholesterol levels, and smoking status showed that hypertension possessed the greatest odds ratio (1.43, 95% CI 1.27-1.60) for carotid plaque among the metabolic/hemodynamic risk factors. These data emphasize the importance of controlling blood pressure for reducing the risk of both metabolic syndrome and carotid arteriosclerosis in apparently healthy individuals.
被称为代谢综合征的一组代谢和血流动力学危险因素，已知是缺血性心血管疾病和中风的危险因素。通过分析8144名接受一般健康筛查的个体（年龄19 - 88岁）的横断面数据，我们调查了代谢综合征的患病率，该患病率根据修改后的美国国家胆固醇教育计划（NCEP）标准诊断，对应以下五类：甘油三酯≥150mg/dl；男性高密度脂蛋白（HDL）胆固醇<40mg/dl，女性<50mg/dl；空腹血糖≥110mg/dl；收缩压/舒张压≥130/85mmHg；体重指数>25kg/m²。我们发现男性代谢综合征患病率为19%，女性为7%。在调整年龄后，发现男性代谢综合征的患病率显著高于女性，优势比为3.08（95%置信区间[CI]2.62 - 3.61，p<0.0001）。在五个代谢/血流动力学危险因素组分中，高血压在代谢综合征个体中最为常见，男性为85%，女性为87%。此外，在调整年龄、性别、血清总胆固醇水平和吸烟状况后的多因素逻辑回归分析显示，在代谢/血流动力学危险因素中，高血压对于颈动脉斑块具有最大的优势比（1.43，95%CI 1.27 - 1.60）。这些数据强调了控制血压对于降低看似健康个体中代谢综合征和颈动脉粥样硬化风险的重要性。
