Qin Linyuan, Wu Xiaoyan, Tan Chao, Zhang Zhengbao, Li You, Zhu Xiaonian, Qin Shenghua, Tan Shengkui
Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi, China.
Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, Guangxi, China.
Front Cardiovasc Med. 2024 May 13;11:1325947. doi: 10.3389/fcvm.2024.1325947. eCollection 2024.
This study aimed to evaluate whether there is a J-curve association between blood pressure (BP) and carotid artery intima-media thickening (CAIT) and estimate the effect of the turning point of BP on CAIT.
Data from 111,494 regular physical examinations conducted on workers and retirees (aged 18 years or older) between January 2011 and December 2016, exported from the hospital information system, were analyzed. Restricted cubic splines (RCS) logistic regression was employed to access the association of BP with CAIT, and Bayesian benchmark dose methods were used to estimate the benchmark dose as the departure point of BP measurements. All the values of BP measurements were less than 0.05 in the RCS logistic regression models. Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) had J-curve associations with the risk of CAIT at a turning point around 120/70 mmHg in the RCS. The benchmark dose for a 1% change in CAIT risk was estimated to be 120.64 mmHg for SBP and 72.46 mmHg for DBP.
The J-curve associations between SBP and DBP and the risk of CAIT were observed in the general population in southern China, and the turning point of blood pressure for significantly reducing the risk of CAIT was estimated to be 120.64/72.46 mmHg for SBP/DBP.
本研究旨在评估血压（BP）与颈动脉内膜中层增厚（CAIT）之间是否存在J型曲线关联，并估计血压转折点对CAIT的影响。
分析了2011年1月至2016年12月期间从医院信息系统导出的111494例工人和退休人员（年龄18岁及以上）定期体检的数据。采用受限立方样条（RCS）逻辑回归分析BP与CAIT的关联，并使用贝叶斯基准剂量方法估计作为BP测量出发点的基准剂量。在RCS逻辑回归模型中，所有BP测量值的P值均小于0.05。收缩压（SBP）和舒张压（DBP）在RCS中约120/70 mmHg的转折点处均与CAIT风险存在J型曲线关联。CAIT风险变化1%的基准剂量估计SBP为120.64 mmHg，DBP为72.46 mmHg。
在中国南方普通人群中观察到SBP和DBP与CAIT风险之间的J型曲线关联，显著降低CAIT风险的血压转折点估计SBP/DBP为120.64/72.46 mmHg。
