Yang Qiaoxia, Lin Qiuxing, Guo Dandan, Wang Hanhua, Liu Jie, Zhang Xin, Tu Jun, Ning Xianjia, Yang Qing, Wang Jinghua
Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Front Cardiovasc Med. 2021 Nov 19;8:669245. doi: 10.3389/fcvm.2021.669245. eCollection 2021.
We aimed to evaluate the relationship between metabolic syndrome (MetS) including its components and carotid intima media thickness (CIMT) in a low-income Chinese population aged ≥45 years. The participants underwent a general health screening and B-mode carotid ultrasonography that measured CIMT. The diagnosis of MetS and its components was based on the modified International Diabetes Federation Criteria for the Asian Population. The univariate and multivariable linear regression analyses were used to evaluate the relationship between MetS and CIMT. A total of 3,583 participants (mean age, 60 years) was included in the analyses (41.4% male and 58.6% female); more than 50% of the participants were diagnosed with MetS. In the multivariable linear regression analysis, the mean CIMT was 0.009 mm greater in the participants with MetS than in those without MetS (β = 0.009; 95% , 0.003-0.014; < 0.05). Moreover, a high number of MetS components was associated with greater CIMT values; for example, CIMT increased by 0.007 and 0.015 mm for the individuals diagnosed with 3-4 and 5 MetS components, respectively. Among the MetS components, elevated blood pressure (β = 0.022; 95% , 0.015-0.029; < 0.001) and abdominal obesity (β = 0.008; 95% , 0.001-0.015; < 0.001) were positively correlated with CIMT. However, the increased triglyceride levels were negatively associated with CIMT (β = -0.008; 95% : -0.015 to -0.002; = 0.012), especially among the elderly population. The risk of carotid atherosclerosis increased in the presence of multiple MetS components in a low-income, middle-aged, and elderly population. Accordingly, more detailed management strategies are essential for the early prevention and intervention of atherosclerosis in this low-income population with MetS, in China.
我们旨在评估≥45岁的低收入中国人群中代谢综合征（MetS）及其各组分与颈动脉内膜中层厚度（CIMT）之间的关系。参与者接受了一般健康筛查和测量CIMT的B型颈动脉超声检查。MetS及其组分的诊断基于针对亚洲人群修改后的国际糖尿病联盟标准。采用单变量和多变量线性回归分析来评估MetS与CIMT之间的关系。分析共纳入3583名参与者（平均年龄60岁）（男性占41.4%，女性占58.6%）；超过50%的参与者被诊断为患有MetS。在多变量线性回归分析中，患有MetS的参与者的平均CIMT比未患MetS的参与者厚0.009mm（β = 0.009；95%置信区间，0.003 - 0.014；P < 0.05）。此外，MetS组分数量较多与更高的CIMT值相关；例如，被诊断患有3 - 4个和5个MetS组分的个体，其CIMT分别增加了0.007mm和0.015mm。在MetS各组分中，血压升高（β = 0.022；95%置信区间，0.015 - 0.029；P < 0.001）和腹型肥胖（β = 0.008；95%置信区间，0.001 - 0.015；P < 0.001）与CIMT呈正相关。然而，甘油三酯水平升高与CIMT呈负相关（β = -0.008；95%置信区间：-0.015至-0.002；P = 0.012），尤其是在老年人群中。在低收入的中老年人群中，存在多个MetS组分时颈动脉粥样硬化风险增加。因此，在中国这个患有MetS的低收入人群中，更详细的管理策略对于动脉粥样硬化的早期预防和干预至关重要。
