Ovsiannikov V I, Berezina T P
Ross Fiziol Zh Im I M Sechenova. 2005 Apr;91(4):437-49.
I.V. administration of serotonin (2 mg kg(-1)) to alert rabbits changed the ileal, caecal, and colon motility including excitatory and inhibitory components. Initial rise of contractile activity was quickly replaced by its diminishing followed by a longer enhancement of the motility, and then by the final, inhibitory, phase. Under blockade of beta1- and beta2-adrenoreceptors with propranolol inhibition of ileal and caecal contractile activity with serotonin was preserved, the effect of circulating catecholamines on beta-adrenoreceptors of smooth muscle cells seems to be excluded as a cause of the serotonin inhibitory effect. In conditions of blockade of pre- and postsynaptic alpha-adrenoreceptors with phentolamine, there was no significant diminishing of the contractile activity in the ileo-caecal zone below the initial level induced by serotonin in control experiments. Intensification of the ileo-caecal zone contractile activity under the effect of serotonin persisted in conditions of blockade of muscarinic cholinoreceptors and was proceeding with participation of non-cholinergic excitatory mechanism.
给清醒的兔子静脉注射血清素（2毫克/千克）会改变回肠、盲肠和结肠的运动，包括兴奋和抑制成分。收缩活动的最初上升很快被其减弱所取代，随后是运动的较长时间增强，然后是最后的抑制阶段。用普萘洛尔阻断β1和β2肾上腺素能受体后，血清素对回肠和盲肠收缩活动的抑制作用得以保留，循环儿茶酚胺对平滑肌细胞β肾上腺素能受体的作用似乎被排除在血清素抑制作用的原因之外。在用酚妥拉明阻断突触前和突触后α肾上腺素能受体的情况下，在对照实验中，回盲部区域的收缩活动没有明显减弱到低于血清素诱导的初始水平。在阻断毒蕈碱型胆碱能受体的情况下，血清素作用下回盲部区域收缩活动的增强持续存在，并且是在非胆碱能兴奋机制的参与下进行的。
