Berezina T P
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Sep;84(9):940-8.
In cats, distention of an isolated segment of the ileum with a saline injection elicited its contraction which could be abolished with blockade of muscarinic receptors. Serotonine acting from the ileum lumen enhanced the response, whereas acting from the vascular bed induced a contractile response which could be decreased with the beta-adrenoreceptor-blocking agent propranolol. The findings suggest a possibility of the serotonine participation in realisation of peristaltic reflex, the character of its modulating effect being dependent on activation of excitatory cholinergic and inhibitory nonadrenergic neurons.
在猫身上，向孤立的回肠段注射生理盐水使其扩张会引发收缩，而这种收缩可通过阻断毒蕈碱受体来消除。从回肠腔起作用的血清素会增强这种反应，而从血管床起作用时则会诱发收缩反应，且该反应可被β-肾上腺素能受体阻滞剂普萘洛尔减弱。这些发现提示血清素有可能参与蠕动反射的实现，其调节作用的特点取决于兴奋性胆碱能神经元和抑制性非肾上腺素能神经元的激活。
