Ovsiannikov V I
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Sep;84(9):920-30.
Myoelectrical activity of the duodenum and ileum was recorded in rabbits with implanted electrode. Acute haemorrhage caused either elevation or reduction of the firing rate, the responses being abolished with a combined blockade of alpha- and beta-adrenoreceptors. Beta-adrenoreceptors agonist isoproterenol resulted in a biphasic (decrease-increase) change of the myoelectrical activity which could be abolished with blockade of beta-adrenoreceptors. The character of the small intestine motor responses to acute haemorrhage and isoproterenol infusion depended on the initial level of the intestinal contractile activity. The findings suggest that catecholamines induce a small intestinal motor effect via stimulation of both inhibitory adrenoreceptors and excitatory presynaptic adrenoreceptors.
用植入电极记录家兔十二指肠和回肠的肌电活动。急性出血可导致放电频率升高或降低，α-和β-肾上腺素能受体联合阻断可消除这些反应。β-肾上腺素能受体激动剂异丙肾上腺素导致肌电活动呈双相（先降低后升高）变化，β-肾上腺素能受体阻断可消除这种变化。小肠对急性出血和输注异丙肾上腺素的运动反应特征取决于肠道收缩活动的初始水平。这些发现表明，儿茶酚胺通过刺激抑制性肾上腺素能受体和兴奋性突触前肾上腺素能受体诱导小肠运动效应。
