Matousková I, Matlerová S, Janoutová G, Janout V
Department of Preventive Medicine, Faculty of Medicine, Palacký University, Olomouc, Czech Republic.
Cent Eur J Public Health. 2005 Jun;13(2):99-102.
To assess the interval since the last revaccination against tetanus the persistence of antibodies was determined using ELISA test in 128 subject. Levels of antibodies against tetanus higher than the protective level of 0.1 IU/ml were found not only in those revaccinated less than ten years ago, but also in those revaccinated more than ten years before. With increasing length of the interval since last revaccination the antibody levels against tetanus decreased gradually although they remained above the protective level. No basic dependence of that trend on gender or age has been found. In the whole series, antibodies against tetanus exceeded the protective level for up to 20-25 years post last revaccination. This finding together with a favorable epidemiological situation as regards the occurrence of tetanus could eventually enable to prolong the interval for revaccinating adults in the Czech Republic.
为评估上次破伤风再接种后的间隔时间，采用酶联免疫吸附测定（ELISA）试验对128名受试者的抗体持久性进行了测定。结果发现，不仅在10年前以内进行过再接种的人群中，而且在10多年前进行过再接种的人群中，破伤风抗体水平均高于0.1 IU/ml的保护水平。随着上次再接种后间隔时间的延长，破伤风抗体水平虽仍高于保护水平，但逐渐下降。未发现该趋势与性别或年龄有基本关联。在整个系列中，上次再接种后，破伤风抗体超过保护水平可达20至25年。这一发现，再加上破伤风发病方面良好的流行病学形势，最终可能使捷克共和国延长成人再接种的间隔时间。
