Menchaca-Mendez Ricardo, Janga Sarath Chandra, Collado-Vides Julio
Program of Computational Genomics, Centro de Ciencias Genómicas (CCG)-UNAM, Morelos, Mexico.
OMICS. 2005 Summer;9(2):139-45. doi: 10.1089/omi.2005.9.139.
Two prokaryotic organisms for which transcriptional regulatory interactions have been well elucidated by experimental means are Escherichia coli and Bacillus subtilis. Here we show, with the help of simulations and from known data, the importance of proximity of the transcription factor gene and the respective regulated gene in regulatory networks. We discuss the importance of the location of external sensing machinery close to the genes for transcription factors that regulate them in light of our finding.
通过实验手段已充分阐明转录调控相互作用的两种原核生物是大肠杆菌和枯草芽孢杆菌。在此，我们借助模拟并依据已知数据，展示了转录因子基因与各自调控基因在调控网络中的接近程度的重要性。鉴于我们的发现，我们讨论了外部传感机制靠近调控它们的转录因子基因的位置的重要性。
