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An experiment on standardized cell culture assay in assessing the activities of Composite Artemisia Capillaris Tablets against hepatitis B virus replication in vitro.

作者信息

Han Jin, Zhao Yan-ling, Shan Li-mei, Huang Feng-jiao, Xiao Xiao-he

机构信息

Department of Pharmacy, 302 Hospital of PLA, Beijing, China.

出版信息

Chin J Integr Med. 2005 Mar;11(1):54-6. doi: 10.1007/BF02835751.

DOI:10.1007/BF02835751
PMID:15975310
Abstract

OBJECTIVE

To explore the activities of Composite Artemisia Capillaris Tablet (CACT) against hepatitis B virus replication in vitro.

METHODS

By means of radioimmunoassay (RIA), Dot blot and Southern blot, the surface and e antigen production of 2.2.15 cells, HBV DNA in 2.2.15 cell culture medium and that in 2.2.15 cells were examined respectively.

RESULTS

HBsAg, HBeAg values of 2.2.15 cells treated by CACT were lower than those of the control, the HBV DNA quantities in culture medium and in 2.2.15 cells decreased as compared with those cells with no treatment by CACT given to them.

CONCLUSION

CACT could inhibit HBV DNA replication, showing its potential antiviral activity in hepatitis B treatment.

摘要

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