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喷昔洛韦是一种在培养的人肝癌细胞中对乙肝病毒复制有选择性抑制作用的药物。

Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.

作者信息

Korba B E, Boyd M R

机构信息

Division of Molecular Virology and Immunology, Georgetown University, Rockville, Maryland, USA.

出版信息

Antimicrob Agents Chemother. 1996 May;40(5):1282-4. doi: 10.1128/AAC.40.5.1282.

DOI:10.1128/AAC.40.5.1282
PMID:8723485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163310/
Abstract

Penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yI)guanine], an effective antiherpesvirus agent, was found to be a potent and selective antiviral agent against intracellular hepatitis B virus (HBV) replication (drug concentration at which a 10-fold decrease in HBV DNA from the average level in an untreated culture was observed [EC90], 1.6 microM) and extracellular virion release (EC90, 0.7 microM) by cultured human hepatoblastoma (2.2.15) cells. Acyclovir and three other related 9-alkoxypurines with activity against either herpesviruses or human immunodeficiency virus were uniformly inactive against HBV. The activity of penciclovir is discussed in relation to recent findings related to its mode of action against HBV.

摘要

喷昔洛韦[9-(4-羟基-3-羟甲基丁-1-基)鸟嘌呤]是一种有效的抗疱疹病毒药物，已被发现是一种针对细胞内乙型肝炎病毒(HBV)复制的强效且具有选择性的抗病毒药物(观察到将未处理培养物中的HBV DNA平均水平降低10倍时的药物浓度[EC90]为1.6微摩尔)，并且对培养的人肝母细胞瘤(2.2.15)细胞的细胞外病毒粒子释放也有抑制作用(EC90为0.7微摩尔)。阿昔洛韦以及其他三种对疱疹病毒或人类免疫缺陷病毒有活性的相关9-烷氧基嘌呤对HBV均无活性。结合最近关于喷昔洛韦抗HBV作用模式的研究结果对其活性进行了讨论。

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本文引用的文献

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Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers.对健康志愿者单次口服125、250、500和750毫克泛昔洛韦后喷昔洛韦的线性药代动力学。
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Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action.无环鸟苷类似物以非常不同的效力抑制DNA聚合酶α、δ和ε，并且具有独特的作用机制。
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Safety of famciclovir in patients with herpes zoster and genital herpes.泛昔洛韦在带状疱疹和生殖器疱疹患者中的安全性。
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