Kim Jong Bin
Ludwig Institute for Cancer Research, First Floor - Breast Cancer Laboratory, Department of Surgery, Royal Free and University College London Medical School, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, UK.
Semin Cancer Biol. 2005 Oct;15(5):365-77. doi: 10.1016/j.semcancer.2005.05.002.
Three-dimensional (3D) tissue culture models have an invaluable role in tumour biology today providing some very important insights into cancer biology. As well as increasing our understanding of homeostasis, cellular differentiation and tissue organization they provide a well defined environment for cancer research in contrast to the complex host environment of an in vivo model. Due to their enormous potential 3D tumour cultures are currently being exploited by many branches of biomedical science with therapeutically orientated studies becoming the major focus of research. Recent advances in 3D culture and tissue engineering techniques have enabled the development of more complex heterologous 3D tumour models.
三维（3D）组织培养模型在当今肿瘤生物学中发挥着不可估量的作用，为癌症生物学提供了一些非常重要的见解。除了增进我们对体内平衡、细胞分化和组织组织的理解外，与体内模型复杂的宿主环境相比，它们为癌症研究提供了一个明确界定的环境。由于其巨大的潜力，3D肿瘤培养目前正被生物医学科学的许多分支所利用，以治疗为导向的研究成为主要研究重点。3D培养和组织工程技术的最新进展使得更复杂的异源3D肿瘤模型得以开发。
