Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia.
Trends Biotechnol. 2010 Mar;28(3):125-33. doi: 10.1016/j.tibtech.2009.12.001. Epub 2010 Jan 6.
Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive most of the attention, it is obvious that other areas of biomedical research could be well served by the powerful tools that have already been developed in tissue engineering. In this article, we review the recent literature to demonstrate how tissue engineering platforms can enhance in vitro and in vivo models of tumorigenesis and thus hold great promise to contribute to future cancer research.
组织工程学的进展传统上导致了支架或基质为基础的培养系统的设计，这些系统更好地反映了天然细胞外基质的生物、物理和生化环境。尽管它们在再生医学中的临床应用往往受到最多的关注，但很明显，组织工程学中已经开发的强大工具可以很好地应用于其他生物医学研究领域。在本文中，我们回顾了最近的文献，以证明组织工程平台如何增强肿瘤发生的体外和体内模型，因此有望为未来的癌症研究做出贡献。
