前列腺癌的分子病理学
Molecular pathology of prostate cancer.
作者信息
Hughes C, Murphy A, Martin C, Sheils O, O'Leary J
机构信息
Pathology Department, Trinity College Dublin and Coombe Women's Hospital, Dublin, Ireland.
出版信息
J Clin Pathol. 2005 Jul;58(7):673-84. doi: 10.1136/jcp.2002.003954.
The molecular pathology of prostate cancer is complex; not only are multiple genes involved in its pathogenesis, but additional environmental factors such as diet and inflammation are also involved. The exhaustive research into prostate cancer to date has demonstrated a complex interaction of multiple genes and environmental factors, some of which may be more important in individual prostate cancer cases. This is an exciting era, with the emergence of new investigative tools such as DNA microarray technology and the application of the field of proteomics to the study of human cancers. Knowledge of genetic changes underlying the initiation, development, and progression of prostate cancer is accumulating rapidly. With increasing knowledge, it may be possible to distinguish indolent from aggressive prostate tumours by molecular fingerprinting. This review discusses the most consistently reported molecular pathological findings in hereditary and sporadic prostate cancer, together with new concepts and technologies.
前列腺癌的分子病理学十分复杂；不仅有多个基因参与其发病机制，饮食和炎症等其他环境因素也与之相关。迄今为止，对前列腺癌的详尽研究已表明多个基因与环境因素之间存在复杂的相互作用，其中一些因素在个别前列腺癌病例中可能更为重要。这是一个令人兴奋的时代，DNA微阵列技术等新研究工具不断涌现，蛋白质组学领域也应用于人类癌症研究。关于前列腺癌起始、发展和进展的潜在基因变化的知识正在迅速积累。随着知识的不断增加，或许有可能通过分子指纹识别区分惰性与侵袭性前列腺肿瘤。本文综述了遗传性和散发性前列腺癌中最常报道的分子病理学发现，以及新的概念和技术。
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