Prieto Jose M, Hanafi Mohd Mukrish Mohd
School of Pharmacy, University College London, London WC1N 1AX, UK.
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.
Curr Issues Mol Biol. 2023 Feb 9;45(2):1536-1567. doi: 10.3390/cimb45020099.
Prostate cancer (PCa) remains both a global health burden and a scientific challenge. We present a review of the molecular targets driving current drug discovery to fight this disease. Moreover, the preventable nature of most PCa cases represents an opportunity for phytochemicals as chemopreventive when adequately integrated into nutritional interventions. With a renovated interest in natural remedies as a commodity and their essential role in cancer drug discovery, Malaysia is looking towards capitalizing on its mega biodiversity, which includes the oldest rainforest in the world and an estimated 1200 medicinal plants. We here explore whether the list of top Malay plants prioritized by the Malaysian government may fulfill the potential of becoming newer, sustainable sources of prostate cancer chemotherapy. These include syn and . Our review highlights the importance of resistance factors such as Smac/DIABLO in cancer progression, the role of the CXCL12/CXCR4 axis in cancer metastasis, and the regulation of PCa cells by some promising terpenes (andrographolide, Asiatic acid, rosmarinic acid), flavonoids (isovitexin, gossypin, sinensetin), and alkylresorcinols (labisiaquinones) among others.
前列腺癌（PCa）仍然是一个全球健康负担和一项科学挑战。我们对推动当前抗该疾病药物研发的分子靶点进行了综述。此外，大多数前列腺癌病例具有可预防性，这为植物化学物质在适当纳入营养干预措施时作为化学预防剂提供了契机。随着人们对天然药物作为一种商品的兴趣重新燃起，以及它们在癌症药物研发中的重要作用，马来西亚正寻求利用其丰富的生物多样性，其中包括世界上最古老的雨林和大约1200种药用植物。我们在此探讨马来西亚政府优先列出的顶级马来植物名单是否有可能成为前列腺癌化疗更新的、可持续的来源。这些植物包括syn和。我们的综述强调了诸如Smac/DIABLO等抗性因子在癌症进展中的重要性、CXCL12/CXCR4轴在癌症转移中的作用，以及一些有前景的萜类化合物（穿心莲内酯、积雪草苷、迷迭香酸）、黄酮类化合物（异荭草素、棉皮素、橙皮素）和烷基间苯二酚（拉比西亚醌）等对前列腺癌细胞的调控作用等。
