基底节梗死患者胎儿猪细胞的神经移植：一项初步安全性和可行性研究。

Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study.

作者信息

Savitz Sean I, Dinsmore Jonathan, Wu Julian, Henderson Galen V, Stieg Philip, Caplan Louis R

机构信息

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. 02215, USA.

出版信息

Cerebrovasc Dis. 2005;20(2):101-7. doi: 10.1159/000086518. Epub 2005 Jun 21.

DOI:10.1159/000086518

PMID:15976503

Abstract

BACKGROUND

Cell transplantation is safe in animal models and enhances recovery from stroke in rats.

METHODS

We studied the safety and feasibility of fetal porcine transplantation in 5 patients with basal ganglia infarcts and stable neurological deficits. To prevent rejection, cells were pretreated with an anti-MHC1 antibody and no immunosuppressive drugs were given to the patients.

RESULTS

The first 3 patients had no adverse cell, procedure, or imaging-defined effects. The fourth patient had temporary worsening of motor deficits 3 weeks after transplantation, and the fifth patient developed seizures 1 week after transplantation. MRI in both patients demonstrated areas of enhancement remote from the transplant site, which resolved on subsequent imaging. Two patients showed improvement in speech, language, and/or motor impairments over several months and persisted at 4 years. The study was terminated by the FDA after the inclusion of 5 patients.

CONCLUSION

This is the first report on the transplantation of nontumor cells in ischemic stroke patients.

摘要

背景

细胞移植在动物模型中是安全的，并且可促进大鼠中风后的恢复。

方法

我们研究了胎儿猪细胞移植在5例基底节梗死且神经功能缺损稳定的患者中的安全性和可行性。为防止排斥反应，细胞用抗MHC1抗体预处理，且未给患者使用免疫抑制药物。

结果

前3例患者未出现不良的细胞、手术或影像学定义的影响。第4例患者在移植后3周出现运动功能缺损暂时恶化，第5例患者在移植后1周出现癫痫发作。两名患者的MRI均显示远离移植部位的强化区域，在后续影像学检查中消失。两名患者在数月内言语、语言和/或运动障碍有所改善，并持续至4年。在纳入5例患者后，该研究被美国食品药品监督管理局终止。