将培养的人神经细胞移植用于中风患者。

Transplantation of cultured human neuronal cells for patients with stroke.

作者信息

Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn K R, Gebel J, Jannetta P, DeCesare S, Elder E M, McGrogan M, Reitman M A, Bynum L

机构信息

Department of Neurological Surgery, University of Pittsburgh Medical Center, PA 15213, USA.

出版信息

Neurology. 2000 Aug 22;55(4):565-9. doi: 10.1212/wnl.55.4.565.

DOI:10.1212/wnl.55.4.565

PMID:10953194

Abstract

Transplantation of cultured neuronal cells is safe in animal models and improves motor and cognitive deficits in rats with stroke. The authors studied the safety and feasibility of human neuronal cellular transplantation in patients with basal ganglia stroke and fixed motor deficits, including 12 patients (aged 44 to 75 years) with an infarct 6 months to 6 years previously (stable for at least 2 months). Serial evaluations (12 to 18 months) showed no adverse cell-related serologic or imaging-defined effects. The total European Stroke Scale score improved in six patients (3 to 10 points), with a mean improvement 2.9 points in all patients (p = 0. 046). Six of 11 PET scans at 6 months showed improved fluorodeoxyglucose uptake at the implant site. Neuronal transplantation is feasible in patients with motor infarction.

摘要

在动物模型中，移植培养的神经元细胞是安全的，并且可改善中风大鼠的运动和认知缺陷。作者研究了人类神经元细胞移植在基底节区中风且存在固定运动功能缺陷患者中的安全性和可行性，其中包括12例患者（年龄44至75岁），他们在6个月至6年前发生过梗死（至少稳定2个月）。连续评估（12至18个月）显示，未出现与细胞相关的不良血清学或影像学界定的影响。6例患者的欧洲卒中量表总分得到改善（提高3至10分），所有患者的平均改善为2.9分（p = 0.046）。6个月时11次PET扫描中的6次显示植入部位的氟脱氧葡萄糖摄取增加。神经元移植对于运动性梗死患者是可行的。