Dahlbom M, Hoffman E J, Hoh C K, Schiepers C, Rosenqvist G, Hawkins R A, Phelps M E
Department of Radiological Sciences, University of California, Los Angeles.
J Nucl Med. 1992 Jun;33(6):1191-9.
Methods for whole-body PET imaging have been developed to provide a clinical tool for the detection and evaluation of primary and metastatic cancers. The axial FOV of the PET system is extended by imaging at multiple bed positions to cover the whole body. In typical rectilinear PET scans, only a small fraction of the data is collected to form two-dimensional projection images. In this work, 100% of the projection data was collected to form the two-dimensional projection images. These projection images were generated for continuous angles over 180 degrees by resorting sinogram data. In addition, tomographic images were formed by using filtered backprojection reconstruction without attenuation correction. Coronal and sagittal cuts were then extracted from the three-dimensional data set. The tomographic images were reconstructed to a resolution of 10.8 mm in all dimensions because of statistical limitations of the data. Both methods of image formation resulted in images of high quality with the tomographic reconstruction providing the highest contrast and resolution. An acquisition time of 1-2 min/bed position after a 10-mCi injection of [18F]fluoride ion or [18F]FDG was found to give a sufficient number of counts for producing images of good resolution and contrast, from a total scanning time of 32-64 min.
全身正电子发射断层扫描（PET）成像方法已被开发出来，以提供一种用于检测和评估原发性及转移性癌症的临床工具。通过在多个床位位置进行成像，PET系统的轴向视野得以扩展，从而覆盖全身。在典型的直线型PET扫描中，仅收集一小部分数据来形成二维投影图像。在这项工作中，收集了100%的投影数据来形成二维投影图像。通过利用正弦图数据，这些投影图像在180度以上的连续角度生成。此外，使用滤波反投影重建法在不进行衰减校正的情况下形成断层图像。然后从三维数据集中提取冠状面和矢状面切片。由于数据的统计限制，断层图像在所有维度上被重建为10.8毫米的分辨率。两种图像形成方法都产生了高质量的图像，其中断层重建提供了最高的对比度和分辨率。在注射10毫居里的[18F]氟离子或[18F]氟代脱氧葡萄糖（FDG）后，每个床位位置1 - 2分钟的采集时间被发现能产生足够数量的计数，从而在32 - 64分钟的总扫描时间内生成具有良好分辨率和对比度的图像。
