Savaskan Egemen
Psychiatric University Clinic, Wilhelm Klein-Str.27, CH-4025 Basel, Switzerland.
Curr Alzheimer Res. 2005 Jan;2(1):29-35. doi: 10.2174/1567205052772740.
The primary function of the renin-angiotensin system (RAS) is to maintain fluid homeostasis and regulate blood pressure. Several components of the RAS, namely angiotensinogen, angiotensin converting enzyme, angiotensin II and their receptors, are found in the CNS suggesting the possibility of a localized RAS in the brain. Cognitively disabling neurodegenerative disorders such as Alzheimer's disease or vascular dementia show vascular lesions, and the brain RAS has been suggested to contribute to the disease process. The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders.
肾素-血管紧张素系统（RAS）的主要功能是维持体液平衡并调节血压。RAS的几个组成部分，即血管紧张素原、血管紧张素转换酶、血管紧张素II及其受体，在中枢神经系统中被发现，这表明大脑中可能存在局部RAS。诸如阿尔茨海默病或血管性痴呆等导致认知功能障碍的神经退行性疾病会出现血管病变，并且有人提出大脑RAS可能参与了疾病进程。这篇简短综述的目的是总结该领域的研究现状，重点关注神经退行性疾病过程中与RAS相关的改变。
