Luppino Giuseppe, Ben Hamed Suliann, Gamberini Michela, Matelli Massimo, Galletti Claudio
Dipartimento di Neuroscienze, Sezione di Fisiologia, Università di Parma, Via Volturno 39, I-43100 Parma, Italy.
Eur J Neurosci. 2005 Jun;21(11):3056-76. doi: 10.1111/j.1460-9568.2005.04149.x.
The anterior wall of the parieto-occipital sulcus (POs) of the macaque monkey, classically considered as part of Brodmann's area 19, contains two functionally distinct areas: a ventral, purely visual area, V6, and a dorsal area, V6A, containing visual neurons and neurons related to the control of arm movements. The aim of this study was to establish whether areas V6 and V6A, so far identified only on a functional basis, have a cytoarchitectonic counterpart. The cytoarchitectonic analysis of 13 hemispheres from ten macaque brains, cut along different planes of section, showed that the anterior wall of the POs contains three distinct areas. One is located in the ventralmost part of the wall, another in the dorsalmost part of the wall, and the third occupies an intermediate position. The ventralmost region displays architectonic features typical of the occipital cytoarchitectonic domain, whereas the two dorsal areas display architectonic features typical of the posterior parietal cortex. Analysis of myeloarchitecture and of the distribution of SMI-32 immunoreactivity confirmed the cytoarchitectonic parcellation. Correlation of cytoarchitectonic maps with functional and hodological data strongly suggests that the ventral region corresponds to area V6, whereas the other two regions correspond to different subsectors of V6A, here named V6Av and V6Ad, respectively. The present data are in line with electrophysiological and hodological data, which suggest that area V6 is a classic extrastriate area, whereas V6A is an area of the posterior parietal cortex. They also suggest that V6A includes two separate cortical subdivisions, a view supported by preliminary functional and hodological data that needs further confirmation.
猕猴顶枕沟（POs）的前壁，传统上被认为是布罗德曼19区的一部分，包含两个功能不同的区域：一个腹侧的、纯粹的视觉区域V6，以及一个背侧区域V6A，其中包含视觉神经元和与手臂运动控制相关的神经元。本研究的目的是确定迄今为止仅在功能基础上确定的V6和V6A区域是否有细胞构筑学上的对应区域。对来自十只猕猴大脑的13个半球沿不同切片平面进行的细胞构筑学分析表明，POs的前壁包含三个不同的区域。一个位于壁的最腹侧部分，另一个位于壁的最背侧部分，第三个占据中间位置。最腹侧区域呈现出枕叶细胞构筑学领域典型的结构特征，而两个背侧区域呈现出顶叶后皮质典型的结构特征。对髓鞘构筑和SMI-32免疫反应分布的分析证实了细胞构筑分区。细胞构筑图与功能和神经传导数据的相关性强烈表明，腹侧区域对应于V6区，而其他两个区域分别对应于V6A的不同子区域，这里分别命名为V6Av和V6Ad。目前的数据与电生理和神经传导数据一致，这些数据表明V6区是一个经典的纹外区，而VIA区是顶叶后皮质的一个区域。它们还表明V6A包括两个独立的皮质亚区，这一观点得到了初步功能和神经传导数据的支持，但需要进一步证实。
