Swierczynski Julian, Korczynska Justyna, Goyke Elzbieta, Adrych Krystian, Raczynska Sylwia, Sledzinski Zbigniew
Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland.
Obes Surg. 2005 Jun-Jul;15(6):803-8. doi: 10.1381/0960892054222678.
Human obesity is associated with increased serum hepatocyte growth factor (HGF) concentration. This study examines whether reduced body fat mass after vertical banded gastroplasty (VBG) is associated with a decrease in serum HGF concentration.
Serum HGF concentration and body weight, BMI, body fat mass, blood pressure, serum leptin, insulin, triacylglycerol, and cholesterol concentrations were studied in 10 obese women before and 1 year after VBG. 10 lean, healthy women were used as controls.
Obese women showed significantly higher serum HGF concentration than control (lean, healthy) subjects. The mean serum HGF concentration decreased significantly 1 year after VBG, but did not reach the value observed in lean women. After VBG, BMI, body fat mass and serum HGF had similar patterns of decrease. Moreover, serum HGF concentration was positively correlated with both BMI (r=0.6, P<0.01) and body fat mass (r=0.6, P<0.01). Before surgery in obese women, elevated blood pressure was observed, which decreased after VBG. Linear regression analysis between blood pressure and serum HGF concentration using all subjects, showed no correlation between either systolic blood pressure and serum HGF concentration (r=.15, P=NS) or between diastolic blood pressure and serum HGF concentration (r=0.1, P=NS). Insulin resistance index (HOMA score), serum leptin, insulin and triacylglycerol concentrations decreased 1 year after VBG. However, serum cholesterol concentration did not change significantly.
These results indicate that VBG results in a reduction in circulating HGF concentration. The reduced body fat mass may contribute in part to the decrease of serum HGF concentration after VBG. Because elevated serum HGF concentration may contribute to the progression of atherosclerosis, the decrease in serum HGF concentration after VBG may be beneficial for obese subjects.
人类肥胖与血清肝细胞生长因子（HGF）浓度升高有关。本研究旨在探讨垂直束带胃成形术（VBG）后体脂量减少是否与血清HGF浓度降低有关。
对10名肥胖女性在VBG术前及术后1年进行血清HGF浓度、体重、BMI、体脂量、血压、血清瘦素、胰岛素、三酰甘油和胆固醇浓度的研究。选取10名体型瘦且健康的女性作为对照。
肥胖女性的血清HGF浓度显著高于对照组（体型瘦且健康的）受试者。VBG术后1年，血清HGF平均浓度显著降低，但未降至瘦女性的水平。VBG术后，BMI、体脂量和血清HGF呈现相似的下降模式。此外，血清HGF浓度与BMI（r = 0.6，P < 0.01）和体脂量（r = 0.6，P < 0.01）均呈正相关。肥胖女性术前血压升高，VBG术后血压降低。对所有受试者进行血压与血清HGF浓度的线性回归分析，结果显示收缩压与血清HGF浓度（r = 0.15，P = 无显著性差异）或舒张压与血清HGF浓度（r = 0.1，P = 无显著性差异）之间均无相关性。VBG术后1年，胰岛素抵抗指数（HOMA评分）、血清瘦素、胰岛素和三酰甘油浓度降低。然而，血清胆固醇浓度无显著变化。
这些结果表明，VBG可导致循环HGF浓度降低。体脂量减少可能部分导致VBG术后血清HGF浓度下降。由于血清HGF浓度升高可能促进动脉粥样硬化的发展，VBG术后血清HGF浓度降低可能对肥胖受试者有益。
