Shinder Michael E, Perachio Adrian A, Kaufman Galen D
University of Texas Medical Branch, 7.102 Medical Research Building, 301 University Boulevard, Galveston, TX 77555-1063, USA.
Brain Res. 2005 Jul 19;1050(1-2):79-93. doi: 10.1016/j.brainres.2005.05.029.
Fos expression in vestibular brainstem and cerebellar regions was evaluated during vestibular adaptation in the Mongolian gerbil. In addition, vestibular adaptation was evaluated in both normal and compensated animals, as vestibular compensation reorganizes the vestibular pathway constraining adaptive processes. Behaviorally, discordant optokinetic and vestibular input induced appropriate high and low gain in horizontal angular vestibuloocular reflex responses. In normal animals, low gain adaptation was more complete than high gain. However, in compensated animals, only low gain adaptation produced adaptive responses both toward and away from the lesion with appropriate gain shifts. High gain adaptation in compensated animals failed to result in gain adaptation for head movements toward the side of the lesion. Fos expression during acute vestibular adaptation in normal animals was found in the flocculus/paraflocculus, the dorsal cap of the inferior olive (IOK), and the prepositus hypoglossi (PrH). Floccular Fos labeling was increased under both high and low gain conditions. IOK and PrH labeling was increased and correlated during low gain conditions, but was reduced and uncorrelated during high gain conditions. The pattern of Fos labeling in compensated animals was asymmetric-favoring the ipsilesional flocculus and contralesional vestibular brainstem. Both compensated high and low gain adaptation groups displayed increased floccular and IOK Fos labeling, but only compensated high gain adaptation produced increased Fos labeling in the medial vestibular nucleus. The behavioral and Fos labeling results are consistent with visual-vestibular adaptation requiring direct vestibular input.
在蒙古沙鼠的前庭适应过程中，对其前庭脑干和小脑区域的Fos表达进行了评估。此外，还对正常动物和代偿动物的前庭适应进行了评估，因为前庭代偿会重新组织限制适应过程的前庭通路。行为学上，不一致的视动和前庭输入在前庭眼动反射水平角反应中诱发了适当的高增益和低增益。在正常动物中，低增益适应比高增益更完整。然而，在代偿动物中，只有低增益适应产生了朝向和远离损伤侧的适应性反应，并伴有适当的增益变化。代偿动物中的高增益适应未能导致头部向损伤侧运动时的增益适应。在正常动物急性前庭适应过程中，发现Fos表达出现在绒球/旁绒球、下橄榄核背帽（IOK）和舌下前置核（PrH）。在高增益和低增益条件下，绒球的Fos标记均增加。在低增益条件下，IOK和PrH标记增加且相关，但在高增益条件下减少且不相关。代偿动物中的Fos标记模式不对称，有利于同侧绒球和对侧前庭脑干。代偿性高增益和低增益适应组的绒球和IOK的Fos标记均增加，但只有代偿性高增益适应在内侧前庭核中产生了增加的Fos标记。行为学和Fos标记结果与视觉-前庭适应需要直接前庭输入一致。
