Cummins D, Bennett D, Fisher-Hoch S P, Farrar B, Machin S J, McCormick J B
Department of Haematology, University College, London.
J Trop Med Hyg. 1992 Jun;95(3):197-201.
Clinical and laboratory findings are reported in nine patients who developed acute encephalopathy during the course of Lassa fever. The encephalopathy manifested 3-17 days after disease onset with confusion, followed rapidly by tremor (seven patients), grand mal convulsions (seven), abnormal posturing (three) and coma (eight); focal neurological signs and evidence of raised intracranial pressure were not seen. Eight patients died, most commonly from respiratory arrest following a protracted fit. Development of encephalopathy did not correlate with the presence of virus in cerebrospinal fluid (CSF), nor with virus antibodies in CSF and/or serum; thus, neither direct cytopathic nor immune-mediated mechanisms seem to be involved in its pathogenesis.
报告了9例在拉沙热病程中发生急性脑病的患者的临床和实验室检查结果。脑病在发病后3 - 17天出现，表现为意识模糊，随后迅速出现震颤（7例）、癫痫大发作（7例）、异常姿势（3例）和昏迷（8例）；未发现局灶性神经体征和颅内压升高的证据。8例患者死亡，最常见的死因是长时间抽搐后呼吸骤停。脑病的发生与脑脊液（CSF）中病毒的存在无关，也与CSF和/或血清中的病毒抗体无关；因此，其发病机制似乎既不涉及直接细胞病变机制，也不涉及免疫介导机制。
