Rapanotti Maria Cristina, Caruso Roberta, Bernardini Sergio, Coletti Valentina, Lo-Coco Francesco, De Rossi Giulio
Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
Leuk Res. 2005 Aug;29(8):975-9. doi: 10.1016/j.leukres.2005.01.010. Epub 2005 Mar 2.
Idiopathic hypereosinophilic syndrome (HES) is a rare disease characterized by tissue involvement and organ dysfunction due to abnormal eosinophil proliferation. Evolution of HES into myeloid or T-cell malignancies has been frequently reported. Here, we describe a case of HES that preceded the occurrence of a high-grade B-lymphoblastic lymphoma in which clonal evolution has been demonstrated at the molecular level.
特发性嗜酸性粒细胞增多综合征（HES）是一种罕见疾病，其特征为嗜酸性粒细胞异常增殖导致组织受累和器官功能障碍。HES演变为髓系或T细胞恶性肿瘤的情况屡有报道。在此，我们描述了一例在高级别B淋巴细胞母细胞淋巴瘤发生之前出现的HES病例，该病例在分子水平上已证实存在克隆进化。
