Ballotta M R, Borghi L, Borin P
Servizio di Anatomia ed Istologia Patologica, Ospedale Civile, Rovigo.
Pathologica. 1995 Dec;87(6):682-4.
We describe the case of a nonimmunocompromised middle age man, who presented with a history of fever, nausea, disturbance of consciousness, peripheral eosinophilia and a bone marrow eosinophilic hyperplasia. A persistent unexplained eosinophilia was initially interpreted as a sign of the hypereosinophilic syndrome because all known causes of secondary eosinophilia had been excluded and there were evidence of multiorgan dysfunction. A cervical lymph node biopsy was remarkable for malignant T cell lymphoma according to the hypothesis that patients with the hypereosinophilic syndrome should be carefully examined for an underlying proliferation of clonal T cells. The patient died of CID after 3 months of hospitalization. At autopsy he was found to have a generalized CMV infection.
我们描述了一名非免疫功能低下的中年男性病例，该患者有发热、恶心、意识障碍、外周血嗜酸性粒细胞增多及骨髓嗜酸性粒细胞增生病史。最初，持续性不明原因的嗜酸性粒细胞增多被解释为高嗜酸性粒细胞综合征的征象，因为已排除所有已知的继发性嗜酸性粒细胞增多原因，且存在多器官功能障碍的证据。根据高嗜酸性粒细胞综合征患者应仔细检查是否存在潜在克隆性T细胞增殖这一假设，颈部淋巴结活检显示为恶性T细胞淋巴瘤。患者住院3个月后死于巨细胞病毒包涵体病（CID）。尸检发现他患有全身性巨细胞病毒感染。
