非快速眼动睡眠期间δ波的大脑关联再探讨。

Cerebral correlates of delta waves during non-REM sleep revisited.

作者信息

Dang-Vu Thien Thanh, Desseilles Martin, Laureys Steven, Degueldre Christian, Perrin Fabien, Phillips Christophe, Maquet Pierre, Peigneux Philippe

机构信息

Cyclotron Research Centre, University of Liege, Belgium.

出版信息

Neuroimage. 2005 Oct 15;28(1):14-21. doi: 10.1016/j.neuroimage.2005.05.028. Epub 2005 Jun 23.

DOI:10.1016/j.neuroimage.2005.05.028

PMID:15979343

Abstract

We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement (NREM) sleep in non-sleep-deprived normal young adults, based on the statistical analysis of a positron emission tomography (PET) sleep data set. One hundred fifteen PET scans were obtained using H(2)(15)O under continuous polygraphic monitoring during stages 2-4 of NREM sleep. Correlations between regional cerebral blood flow (rCBF) and delta power (1.5-4 Hz) spectral density were analyzed using statistical parametric mapping (SPM2). Delta power values obtained at central scalp locations negatively correlated during NREM sleep with rCBF in the ventromedial prefrontal cortex, the basal forebrain, the striatum, the anterior insula, and the precuneus. These regions embrace the set of brain areas in which rCBF decreases during slow wave sleep (SWS) as compared to Rapid Eye Movement (REM) sleep and wakefulness (Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. Functional neuroanatomy of human slow wave sleep. J. Neurosci. 17, 2807-S2812), supporting the notion that delta activity is a valuable prominent feature of NREM sleep. A strong association was observed between rCBF in the ventromedial prefrontal regions and delta power, in agreement with electrophysiological studies. In contrast to the results of a previous PET study investigating the brain correlates of delta activity (Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, B.E., 1997. Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. J. Neurosci. 17, 4800-4808), in which waking scans were mixed with NREM sleep scans, no correlation was found with thalamus activity. This latter result stresses the importance of an extra-thalamic delta rhythm among the synchronous NREM sleep oscillations. Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep.

摘要

我们旨在基于对正电子发射断层扫描（PET）睡眠数据集的统计分析，来表征非睡眠剥夺的正常年轻成年人在非快速眼动（NREM）睡眠期间δ活动的神经关联。在NREM睡眠的2 - 4期持续多导睡眠监测下，使用H₂¹⁵O获得了115次PET扫描。使用统计参数映射（SPM2）分析了局部脑血流量（rCBF）与δ功率（1.5 - 4Hz）频谱密度之间的相关性。在NREM睡眠期间，中央头皮位置获得的δ功率值与腹内侧前额叶皮质、基底前脑、纹状体、前岛叶和楔前叶的rCBF呈负相关。与快速眼动（REM）睡眠和清醒状态相比，这些区域包含了慢波睡眠（SWS）期间rCBF降低的一组脑区（Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J.M., Luxen, A., Franck, G., 1997. 人类慢波睡眠的功能神经解剖学。《神经科学杂志》, 17, 2807-S2812），支持了δ活动是NREM睡眠一个有价值的突出特征这一观点。腹内侧前额叶区域的rCBF与δ功率之间观察到强关联，这与电生理研究结果一致。与之前一项研究δ活动的脑关联的PET研究结果（Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A.C., Jones, B.E.,1997. 人类慢波睡眠期间局部脑血流量变化与δ和纺锤波活动的关系。《神经科学杂志》, 17, 4800 - 4808）不同，在该研究中清醒扫描与NREM睡眠扫描混合，未发现与丘脑活动相关。后一结果强调了在同步的NREM睡眠振荡中丘脑外δ节律的重要性。因此，这种rCBF分布可能优先反映了NREM睡眠期间参与皮质δ波产生的细胞过程的特定调节。