Reiter Alexander M, Lewis John R, Okuda Ayako
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
Vet Clin North Am Small Anim Pract. 2005 Jul;35(4):913-42, vii. doi: 10.1016/j.cvsm.2005.03.006.
Based on recent findings of increased vitamin D activity in cats with feline odontoclastic resorptive lesions (FORL), the present article provides further clues on the possible etiology of FORL. Microscopic features of FORL and other peculiarities of feline permanent teeth are compared with pathologic findings obtained from experimental studies in other species. Administration of excess vitamin D or vitamin D metabolites in laboratory animals caused changes to dental and periodontal tissues that resemble histopathologic features of teeth from cats with FORL. Chronic excess dietary vitamin D may be the long-sought cause of multiple tooth resorption in domestic cats. It may also provide a basis for future research on idiopathic hypercalcemia and renal disease in the same species.
基于近期在患有猫牙骨质吸收性病变（FORL）的猫中发现维生素D活性增加，本文提供了关于FORL可能病因的进一步线索。将FORL的微观特征和猫恒牙的其他特点与从其他物种的实验研究中获得的病理结果进行了比较。在实验动物中给予过量的维生素D或维生素D代谢物会导致牙齿和牙周组织发生变化，这些变化类似于患有FORL的猫的牙齿组织病理学特征。长期过量摄入膳食维生素D可能是家猫多颗牙齿吸收这一长期探寻的病因。它也可能为同一物种中特发性高钙血症和肾病的未来研究提供基础。
