体重、体重指数与卵巢癌风险：一项中国的病例对照研究。

Body weight and body mass index and ovarian cancer risk: a case-control study in China.

作者信息

Zhang Min, Xie Xing, Holman C D'Arcy J

机构信息

School of Population Health, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

出版信息

Gynecol Oncol. 2005 Aug;98(2):228-34. doi: 10.1016/j.ygyno.2005.04.026.

DOI:10.1016/j.ygyno.2005.04.026

PMID:15979697

Abstract

OBJECTIVE

To investigate the association between ovarian cancer risk and body height, weight, and BMI.

METHODS

A hospital-based case-control study was conducted in China from 1999 to 2000. The study sample included 254 cases with histologically confirmed epithelial ovarian cancer and 652 controls. Information of adult height and weight at diagnosis, at 5 years before diagnosis and at age 21 years, was collected by face-to-face interview using a structured questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using unconditional logistic regression analyses.

RESULTS

The ovarian cancer risk was significantly increased with higher body weight and BMI at 5 years before diagnosis, but not at diagnosis nor at age 21 years. The adjusted ORs were 1.67 (95% CI = 1.04-2.67) for body weight >60 kg versus < or =50 kg and 1.75 (95% CI = 1.13-2.72) for BMI > or = 25.0 versus 18.5-21.9 at 5 years before diagnosis. There was no association between body height and ovarian cancer risk.

CONCLUSION

Pre-morbid body weight and BMI were associated with an increased risk of ovarian cancer in Chinese women.

摘要

目的

探讨卵巢癌风险与身高、体重及体重指数（BMI）之间的关联。

方法

1999年至2000年在中国开展了一项基于医院的病例对照研究。研究样本包括254例经组织学确诊的上皮性卵巢癌患者和652例对照。通过使用结构化问卷进行面对面访谈，收集了确诊时、确诊前5年以及21岁时的成人身高和体重信息。采用非条件逻辑回归分析获得比值比（OR）和95%置信区间（CI）。

结果

确诊前5年体重和BMI较高时，卵巢癌风险显著增加，但确诊时及21岁时并非如此。确诊前5年，体重>60 kg 与≤50 kg相比，调整后的OR为1.67（95%CI = 1.04 - 2.67）；BMI≥25.0与18.5 - 21.9相比，调整后的OR为1.75（95%CI = 1.13 - 2.72）。身高与卵巢癌风险之间无关联。