Cantatore Francesco Paolo, Crivellato Enrico, Nico Beatrice, Ribatti Domenico
Department of Rheumatology, University of Foggia Medical School, Foggia, Italy.
Cell Biol Int. 2005 Jul;29(7):583-5. doi: 10.1016/j.cellbi.2005.03.011.
The exact function of osteocalcin (OC), a protein synthesized by osteoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti-angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF-2, a well-known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation.
骨钙素（OC）是成骨细胞在基质矿化阶段合成的一种蛋白质，其确切功能尚不清楚。在本研究中，我们研究了OC促进鸡胚绒毛尿囊膜（CAM）血管增殖的能力，CAM是一种成熟的体内血管生成和抗血管生成检测方法。结果表明，OC刺激血管生成，且该反应与用FGF-2（一种著名的血管生成细胞因子）获得的反应相似。先前已证明OC参与骨修复，因此这里报道的血管生成活性可能在骨形成中也起关键作用。
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