Sihn Gabin, Walter Thomas, Klein Jean-Claude, Queguiner Isabelle, Iwao Hiroshi, Nicolau Claude, Lehn Jean-Marie, Corvol Pierre, Gasc Jean-Marie
Laboratoire de Pathologie Vasculaire et Endocrinologie Rénale, Inserm U36, Collège de France, 11, place Marcelin Berthelot, 75005 Paris, France.
FEBS Lett. 2007 Mar 6;581(5):962-6. doi: 10.1016/j.febslet.2007.01.079. Epub 2007 Feb 14.
We investigate here the anti-angiogenic properties of the synthetic compound myo-inositol trispyrophosphate (ITPP). By increasing oxy-haemoglobin dissociation, ITPP has the potential to counteract the effects of hypoxia, a critical regulator of angiogenesis and cancer progression. ITPP inhibited angiogenesis of the chorioallantoic membrane (CAM), as analyzed with an original program dedicated to automated quantification of angiogenesis in this model. ITPP also markedly reduced tumor progression and angiogenesis in an experimental model of U87 glioma cell nodules grafted onto the CAM. These results point out the potential of ITPP for the development of a new class of anti-angiogenic and anti-cancer compounds.
我们在此研究合成化合物肌醇三磷酸（ITPP）的抗血管生成特性。通过增加氧合血红蛋白解离，ITPP有潜力抵消缺氧的影响，缺氧是血管生成和癌症进展的关键调节因子。如用专门用于该模型中血管生成自动定量分析的原始程序所分析的那样，ITPP抑制了尿囊绒膜（CAM）的血管生成。在移植到CAM上的U87胶质瘤细胞结节的实验模型中，ITPP还显著降低了肿瘤进展和血管生成。这些结果指出了ITPP在开发新型抗血管生成和抗癌化合物方面的潜力。
