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受体FepA、Fiu和Cir对微菌素E492的协同摄取以及铁载体肠螯合素及其二聚体和三聚体水解产物的抑制作用。

Cooperative uptake of microcin E492 by receptors FepA, Fiu, and Cir and inhibition by the siderophore enterochelin and its dimeric and trimeric hydrolysis products.

作者信息

Strahsburger Erwin, Baeza Marcelo, Monasterio Octavio, Lagos Rosalba

机构信息

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):3083-6. doi: 10.1128/AAC.49.7.3083-3086.2005.

DOI:10.1128/AAC.49.7.3083-3086.2005
PMID:15980406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168642/
Abstract

Microcin E492 uptake by FepA, Fiu, and Cir is cooperative, with FepA being the main receptor. No TonB-mediated interaction with the ferric catecholate receptors is needed for microcin to exert action at the cytoplasmic membrane. Microcin E492 uptake by the receptors is inhibited by the dimer and trimer of dihydroxybenzoylserine.

摘要

FepA、Fiu和Cir对微菌素E492的摄取具有协同作用，其中FepA是主要受体。微菌素在细胞质膜发挥作用时，不需要TonB介导与儿茶酚铁受体相互作用。二羟基苯甲酰丝氨酸的二聚体和三聚体可抑制受体对微菌素E492的摄取。

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本文引用的文献

1
Conformational spread: the propagation of allosteric states in large multiprotein complexes.构象传播：变构状态在大型多蛋白复合物中的传播。
Annu Rev Biophys Biomol Struct. 2004;33:53-73. doi: 10.1146/annurev.biophys.33.110502.132703.
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Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity.铁载体肽，一种新型的具有强大活性的翻译后修饰抗菌肽。
J Biol Chem. 2004 Jul 2;279(27):28233-42. doi: 10.1074/jbc.M400228200. Epub 2004 Apr 21.
3
The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore receptors FepA, Cir, Fiu and IroN.大肠杆菌素G、H和X决定簇编码微菌素M和H47，它们可能利用儿茶酚盐铁载体受体FepA、Cir、Fiu和IroN。
Microbiology (Reading). 2003 Sep;149(Pt 9):2557-2570. doi: 10.1099/mic.0.26396-0.
4
Microcin E492 antibacterial activity: evidence for a TonB-dependent inner membrane permeabilization on Escherichia coli.微菌素E492的抗菌活性：大肠杆菌中依赖TonB的内膜通透性的证据
Mol Microbiol. 2003 Aug;49(4):1031-41. doi: 10.1046/j.1365-2958.2003.03610.x.
5
The expression of genes involved in microcin maturation regulates the production of active microcin E492.参与微菌素成熟的基因表达调控活性微菌素E492的产生。
Biochimie. 2002 May-Jun;84(5-6):539-44. doi: 10.1016/s0300-9084(02)01415-3.
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Ton-dependent colicins and microcins: modular design and evolution.依赖TonB的大肠杆菌素和微菌素：模块化设计与进化
Biochimie. 2002 May-Jun;84(5-6):365-80. doi: 10.1016/s0300-9084(02)01427-x.
7
Quantification of known components of the Escherichia coli TonB energy transduction system: TonB, ExbB, ExbD and FepA.大肠杆菌TonB能量转导系统已知组分的定量分析：TonB、ExbB、ExbD和FepA。
Mol Microbiol. 2002 Apr;44(1):271-81. doi: 10.1046/j.1365-2958.2002.02880.x.
8
Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines.微小菌素E492是一种来自肺炎克雷伯菌的形成通道的细菌素，可诱导某些人类细胞系发生凋亡。
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2696-701. doi: 10.1073/pnas.052709699.
9
Microcin E492 is an unmodified peptide related in structure to colicin V.微菌素E492是一种结构上与大肠杆菌素V相关的未修饰肽。
Antimicrob Agents Chemother. 2002 Jan;46(1):229-30. doi: 10.1128/AAC.46.1.229-230.2002.
10
Structure, organization and characterization of the gene cluster involved in the production of microcin E492, a channel-forming bacteriocin.与形成通道的细菌素微菌素E492产生相关的基因簇的结构、组织及特性分析
Mol Microbiol. 2001 Oct;42(1):229-43. doi: 10.1046/j.1365-2958.2001.02630.x.