作为疾病介质的天然产物。
Natural products as mediators of disease.
作者信息
Garg Neha, Luzzatto-Knaan Tal, Melnik Alexey V, Caraballo-Rodríguez Andrés Mauricio, Floros Dimitrios J, Petras Daniel, Gregor Rachel, Dorrestein Pieter C, Phelan Vanessa V
机构信息
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093, USA.
出版信息
Nat Prod Rep. 2017 Feb 1;34(2):194-219. doi: 10.1039/c6np00063k. Epub 2016 Nov 22.
Abstract
Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.
摘要
涵盖范围
截至2016年
人类是行走的微生物生态系统，每个人都拥有一个复杂的微生物群，其具有产生大量天然产物的遗传潜力。最近的测序数据表明，我们体内的微生物居民对于维持整体健康至关重要。微生物群落的变化与多种疾病相关，包括感染、炎症、癌症和神经紊乱。其中一些具有临床和诊断意义的表型是小分子存在的结果，但我们对它们对个体健康的贡献知之甚少。在这里，我们综述了微生物衍生的天然产物作为人类疾病的介质。
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本文引用的文献
1
Two more pieces of the colibactin genotoxin puzzle from show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.来自[具体来源未提及]的关于大肠杆菌素基因毒素谜题的另外两个片段显示出一种不寻常的1-氨基环丙烷羧酸部分的掺入。
Chem Sci. 2015 May 1;6(5):3154-3160. doi: 10.1039/c5sc00101c. Epub 2015 Mar 24.
2
Discovery of MRSA active antibiotics using primary sequence from the human microbiome.利用人类微生物组的一级序列发现耐甲氧西林金黄色葡萄球菌活性抗生素。
Nat Chem Biol. 2016 Dec;12(12):1004-1006. doi: 10.1038/nchembio.2207. Epub 2016 Oct 17.
3
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.基于比较质谱的代谢组学策略用于微生物次级代谢产物的研究。
Nat Prod Rep. 2017 Jan 4;34(1):6-24. doi: 10.1039/c6np00048g.
4
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.不同的生物合成产生一种含细胞毒性氨基丙二酸的前大肠杆菌素。
Nat Chem Biol. 2016 Oct;12(10):773-5. doi: 10.1038/nchembio.2157. Epub 2016 Aug 22.
5
New insights into the mode of action of the lantibiotic salivaricin B.深入了解羊毛硫抗生素唾液菌素 B 的作用模式。
Sci Rep. 2016 Aug 16;6:31749. doi: 10.1038/srep31749.
6
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Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.
7
Human commensals producing a novel antibiotic impair pathogen colonization.人类共生菌产生新型抗生素可破坏病原体定植。
Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634.
8
Microbiome-wide association studies link dynamic microbial consortia to disease.微生物组关联研究将动态微生物群落与疾病联系起来。
Nature. 2016 Jul 7;535(7610):94-103. doi: 10.1038/nature18850.
9
Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling.通过培养富集分子谱分析捕捉人类肠道微生物群的多样性。
Genome Med. 2016 Jul 1;8(1):72. doi: 10.1186/s13073-016-0327-7.
10
Specificity and complexity in bacterial quorum-sensing systems.细菌群体感应系统中的特异性与复杂性。
FEMS Microbiol Rev. 2016 Sep;40(5):738-52. doi: 10.1093/femsre/fuw014. Epub 2016 Jun 26.
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