Garg Neha, Luzzatto-Knaan Tal, Melnik Alexey V, Caraballo-Rodríguez Andrés Mauricio, Floros Dimitrios J, Petras Daniel, Gregor Rachel, Dorrestein Pieter C, Phelan Vanessa V
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093, USA.
Nat Prod Rep. 2017 Feb 1;34(2):194-219. doi: 10.1039/c6np00063k. Epub 2016 Nov 22.
Covering: up to 2016Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe-derived natural products as mediators of human disease.
截至2016年
人类是行走的微生物生态系统,每个人都拥有一个复杂的微生物群,其具有产生大量天然产物的遗传潜力。最近的测序数据表明,我们体内的微生物居民对于维持整体健康至关重要。微生物群落的变化与多种疾病相关,包括感染、炎症、癌症和神经紊乱。其中一些具有临床和诊断意义的表型是小分子存在的结果,但我们对它们对个体健康的贡献知之甚少。在这里,我们综述了微生物衍生的天然产物作为人类疾病的介质。