两性霉素3的多元醇结构域。整个C(1)-C(30)片段的立体选择性合成。

The polyol domain of amphidinol 3. A stereoselective synthesis of the entire C(1)-C(30) sector.

作者信息

Paquette Leo A, Chang Shuh-Kuen

机构信息

Evans Chemical Laboratories, The Ohio State University, Columbus, 43210, USA.

出版信息

Org Lett. 2005 Jul 7;7(14):3111-4. doi: 10.1021/ol0511833.

DOI:10.1021/ol0511833

PMID:15987218

Abstract

[structure: see text] The richly oxygenated C(1)-C(30) polyol segment of amphidinol 3 has been synthesized in protected form. Incorporated in this long chain are 10 of the 25 stereogenic centers housed in the target. The asymmetric pathway that has been developed is based on the efficient union of three independently prepared subunits.

摘要

[结构：见文本] 两性霉素3中富含氧的C(1)-C(30)多元醇片段已以受保护的形式合成。该长链中包含了目标物中25个手性中心中的10个。所开发的不对称合成途径基于三个独立制备的亚基的有效结合。