Beyer John L, Taylor Warren D, MacFall James R, Kuchibhatla Maragatha, Payne Martha E, Provenzale James M, Cassidy Frederick, Krishnan K Ranga R
Department of Psychiatry and Behavioral Science, Duke University Medical Center, Box 3519 DUMC, Durham, NC 27710, USA.
Neuropsychopharmacology. 2005 Dec;30(12):2225-9. doi: 10.1038/sj.npp.1300802.
This article reports on preliminary findings describing microstructural abnormalities in the white matter of cortical areas thought to be associated with bipolar disorder. In all, 14 patients with bipolar disorder and 21 nonpsychiatrically ill control subjects underwent MR imaging including a diffusion tensor imaging (DTI) pulse sequence (six directions, b=1000 mm(2)/s). DTI data were analyzed on a workstation using a program that allowed calculation of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) within the following three white matter fiber tracts bilaterally: the orbital frontal cortex, and the superior and middle frontal gyri. These values were compared across patient groups. The left and right orbital frontal white matter exhibited significantly higher ADC values in bipolar subjects than control subjects on both the left (p=0.028) and right (p=0.011). Microstructural changes in the white matter of the orbital frontal areas as reflected by increased ADC values appear to be associated with bipolar disorder. Further research is needed to better understand the interaction of microstructural changes and bipolar symptoms and whether these changes are specific to bipolar disorder.
本文报道了关于皮质区域白质微观结构异常的初步研究结果，这些皮质区域被认为与双相情感障碍有关。共有14名双相情感障碍患者和21名无精神疾病的对照受试者接受了磁共振成像检查，包括扩散张量成像（DTI）脉冲序列（六个方向，b = 1000 mm²/s）。在工作站上使用一个程序对DTI数据进行分析，该程序允许计算双侧以下三个白质纤维束内的表观扩散系数（ADC）和分数各向异性（FA）：眶额皮质以及额上回和额中回。对这些值在不同患者组之间进行了比较。双相情感障碍患者的左右眶额白质在左侧（p = 0.028）和右侧（p = 0.011）的ADC值均显著高于对照受试者。ADC值升高所反映的眶额区域白质微观结构变化似乎与双相情感障碍有关。需要进一步研究以更好地理解微观结构变化与双相情感障碍症状之间的相互作用，以及这些变化是否为双相情感障碍所特有。
