Mood Disorders Clinic & Clinical Affective Neuroscience Laboratory, Department of Psychiatry, Seoul National University Bundang Hospital, 166 Gumiro, Bundang-gu, Seongnam-si, Kyeonggi-do 463-707, Republic of Korea.
Neurosci Lett. 2011 Nov 14;505(2):150-4. doi: 10.1016/j.neulet.2011.10.009. Epub 2011 Oct 12.
Differences and similarities in microstructural white matter alterations between bipolar I and bipolar II disorder were investigated. Twelve patients with bipolar I disorder, 12 patients with bipolar II disorder and 22 healthy controls underwent diffusion tensor imaging. Fractional anisotropy (FA) and mean apparent diffusion coefficient (ADC) maps were compared between groups using voxel-based whole brain analyses. Both bipolar I and II groups had a FA decrease in the corpus callosum, cingulate and right prefrontal regions, and a ADC increase in the medial frontal, anterior cingulate, insular and temporal regions, compared to controls. The bipolar I group had a FA decrease in the right temporal white matter and a ADC increase in the frontal, temporal, parietal and thalamic regions, compared to the bipolar II group. The results suggest disrupted integrity of commissural fibers and white matter in the anterior paralimbic structures in bipolar disorder. Relative sparing of the dorsal system and long association fibers may differentiate bipolar II from I disorder.
研究了双相情感障碍 I 型和双相情感障碍 II 型之间的微观结构白质改变的差异和相似之处。12 名双相情感障碍 I 型患者、12 名双相情感障碍 II 型患者和 22 名健康对照者接受了弥散张量成像。采用基于体素的全脑分析比较了组间的分数各向异性 (FA) 和平均表观扩散系数 (ADC) 图。与对照组相比，I 型和 II 型双相障碍组的胼胝体、扣带回和右侧前额叶区域的 FA 降低，内侧额叶、前扣带回、岛叶和颞叶区域的 ADC 增加。与 II 型双相障碍组相比，I 型双相障碍组的右侧颞叶白质 FA 降低，额叶、颞叶、顶叶和丘脑区域的 ADC 增加。结果表明，双相情感障碍患者的联络纤维和前边缘结构的白质完整性受损。背侧系统和长联合纤维的相对保留可能将 II 型双相障碍与 I 型双相障碍区分开来。
