Iannaccone Umberto, Bergamaschi Antonio, Magrini A, Marino Giuseppe, Bottini Nunzio, Lucarelli Paola, Bottini Egidio, Gloria-Bottini Fulvia
Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, 00123 Rome Italy.
Metabolism. 2005 Jul;54(7):891-4. doi: 10.1016/j.metabol.2005.02.002.
Acid phosphatase locus 1 (ACP 1 ) or cytosolic low molecular weight protein tyrosine phosphatase is a polymorphic enzyme that can hydrolyze phosphotyrosine-containing peptides of the human insulin receptor and of band 3 protein. High-activity ACP 1 may favor an increase in serum glucose concentration through a depression of insulin action and through inactivation of aldolase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase induced by dephosphorylation of band 3 protein. In diabetic subjects, we have previously reported lower serum glucose concentration in subjects with low-activity ACP 1 A and AB phenotypes. We have now studied the relationship between serum glucose concentration and ACP 1 genotype in a sample of 137 healthy adult workers of our university. In males, serum glucose concentration is significantly higher in medium-high- than in low-activity ACP 1 genotypes. With advancing age in males, there is a progressive increase in glycemic differential between medium-high- and low-activity ACP 1 genotypes. The data suggest that normal variability of ACP 1 genotype influences serum glucose concentration in normal individuals. Such influence depends on sex and in males becomes more marked with advancing age.
酸性磷酸酶基因座1（ACP 1）或胞质低分子量蛋白酪氨酸磷酸酶是一种多态性酶，可水解人胰岛素受体和带3蛋白中含磷酸酪氨酸的肽段。高活性ACP 1可能通过抑制胰岛素作用以及使带3蛋白去磷酸化诱导的醛缩酶、磷酸果糖激酶和甘油醛-3-磷酸脱氢酶失活，从而促进血清葡萄糖浓度升高。在糖尿病患者中，我们之前报道过具有低活性ACP 1 A和AB表型的患者血清葡萄糖浓度较低。我们现在在我校137名健康成年工作者的样本中研究了血清葡萄糖浓度与ACP 1基因型之间的关系。在男性中，中高活性ACP 1基因型者的血清葡萄糖浓度显著高于低活性ACP 1基因型者。随着男性年龄的增长，中高活性与低活性ACP 1基因型之间的血糖差异逐渐增大。数据表明，ACP 1基因型的正常变异性会影响正常个体的血清葡萄糖浓度。这种影响取决于性别，在男性中随着年龄增长变得更加明显。
