Park Hye Soon, Lee Ki-Up, Kim Young Seol, Park Cheol Young
Department of Family Medicine, Asian Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Metabolism. 2005 Jul;54(7):925-9. doi: 10.1016/j.metabol.2005.02.007.
Recent findings suggest that ghrelin may have a beneficial effect on vasculature. In the present study, we examined the associations between plasma ghrelin concentration and metabolic parameters in children and adolescents. We measured fasting plasma ghrelin concentrations in 50 Korean children and adolescents (28 boys and 22 girls, mean +/- SD age 12.6 +/- 2.7 years, body mass index 22.7 +/- 5.1 kg/m 2 ), and analyzed the associations between fasting plasma ghrelin level and anthropometric measurements, metabolic parameters, leptin concentration, and fasting insulin level. We found that fasting plasma ghrelin concentration was negatively correlated with height, weight, body mass index, percent body fat, waist circumference, and hip circumference in both boys and girls. Fasting plasma ghrelin levels were significantly negatively correlated with triglycerides and fasting insulin levels and positively correlated with high-density lipoprotein cholesterol in boys, but not in girls. Our results thus demonstrate that higher plasma ghrelin levels have beneficial effects on metabolic parameters in boys and that the relationships between fasting plasma ghrelin levels and metabolic parameters differed according to sex.
最近的研究结果表明，胃饥饿素可能对血管系统有有益作用。在本研究中，我们调查了儿童和青少年血浆胃饥饿素浓度与代谢参数之间的关联。我们测量了50名韩国儿童和青少年（28名男孩和22名女孩，平均年龄±标准差为12.6±2.7岁，体重指数为22.7±5.1kg/m²）的空腹血浆胃饥饿素浓度，并分析了空腹血浆胃饥饿素水平与人体测量指标、代谢参数、瘦素浓度和空腹胰岛素水平之间的关联。我们发现，男孩和女孩的空腹血浆胃饥饿素浓度均与身高、体重、体重指数、体脂百分比、腰围和臀围呈负相关。空腹血浆胃饥饿素水平在男孩中与甘油三酯和空腹胰岛素水平显著负相关，与高密度脂蛋白胆固醇正相关，但在女孩中并非如此。因此，我们的结果表明，较高的血浆胃饥饿素水平对男孩的代谢参数有有益作用，并且空腹血浆胃饥饿素水平与代谢参数之间的关系因性别而异。
