Yilmaz Erdal, Ustundag Bilal, Sen Yasar, Akarsu Saadet, Kurt A Nese citak, Dogan Yasar
Division of Pediatric Cardiology, Department of Pediatrics, School of Medicine, Firat University, Elaziğ 23119, Turkey.
Mediators Inflamm. 2007;2007:32403. doi: 10.1155/2007/32403.
BACKGROUND/AIM: Ghrelin has effects on nutrient intake and growth. The cause of growth retardation in congenital heart disease is multifactorial. The aim of the present study is to investigate the ghrelin in congenital heart disease and the association of ghrelin with TNF-alpha and IL-6. Materials and methods. We measured serum ghrelin, TNF-alpha, and IL-6 levels using specific immunoassay in 68 patients (47 acyanotic, 21 cyanotic with congenital heart disease) and in 25 control subjects. Results. In comparison to controls, serum ghrelin, TNF-alpha levels were significantly higher in acyanotic patients and cyanotic patients with congenital heart disease (P<.0001). In acyanotic and cyanotic patients with congenital heart disease, there was a positive correlation between ghrelin and TNF-alpha (r=.485, P<.05 and r=.573, P<.01, resp.).
Serum ghrelin levels is elevated in acyanotic and cyanotic patients with congenital heart disease. Increased ghrelin levels represents malnutrition and growth retardation in these patients. The relation of ghrelin with cytokines may be explained by the possible effect of chronic congestive heart failure and chronic shunt hypoxemia.
背景/目的：胃饥饿素对营养摄入和生长有影响。先天性心脏病生长发育迟缓的原因是多因素的。本研究的目的是调查先天性心脏病患者体内的胃饥饿素，以及胃饥饿素与肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的关联。材料与方法。我们采用特异性免疫分析法，对68例患者（47例非青紫型、21例青紫型先天性心脏病患者）和25例对照者测定血清胃饥饿素、TNF-α和IL-6水平。结果。与对照组相比，非青紫型患者和青紫型先天性心脏病患者的血清胃饥饿素、TNF-α水平显著更高（P<0.0001）。在非青紫型和青紫型先天性心脏病患者中，胃饥饿素与TNF-α之间存在正相关（分别为r = 0.485，P<0.05和r = 0.573，P<0.01）。
非青紫型和青紫型先天性心脏病患者的血清胃饥饿素水平升高。胃饥饿素水平升高表明这些患者存在营养不良和生长发育迟缓。胃饥饿素与细胞因子之间的关系可能由慢性充血性心力衰竭和慢性分流性低氧血症的可能作用来解释。
