Park Hye Young, Yi Kayoung, Kim Ha Kyoung
Department of Ophthalmology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
Korean J Ophthalmol. 2005 Jun;19(2):122-7. doi: 10.3341/kjo.2005.19.2.122.
This study investigated firstly the change of intraocular pressure (IOP) after injection of intravitreal triamcinolone acetonide (IVTA) for the treatment of macular edema and secondly the factors that influence these changes.
A prospective, non-comparative study was performed in 60 patients at Kangnam Sacred Heart Hospital from October 2003 to September 2004. All the patients received 4-mg IVTA injection.
Mean IOP was elevated from the day after injection and peaked at 20.5 mmHg after 2 months (p=0.000). Twenty-six eyes (43.3%) showed significant IOP elevation. IOP was not controlled despite full glaucoma medication in 7 (11.7%) eyes. Two eyes underwent filtering surgery. Younger age was a statistically significant predictive factor for IOP elevation (p=0.009).
In this study, patients who needed filtering surgery developed an IOP spike within one week after the injection. Therefore, clinicians should consider checking IOP at the end of the first week. Furthermore, greater cautions is mandatory with relatively younger patients.
本研究首先调查玻璃体内注射曲安奈德（IVTA）治疗黄斑水肿后眼压（IOP）的变化，其次调查影响这些变化的因素。
2003年10月至2004年9月在江南圣心医院对60例患者进行了一项前瞻性、非对照研究。所有患者均接受4毫克IVTA注射。
注射后次日平均眼压开始升高，2个月后达到峰值20.5毫米汞柱（p = 0.000）。26只眼（43.3%）眼压显著升高。7只眼（11.7%）尽管使用了全部青光眼药物眼压仍未得到控制。2只眼接受了滤过手术。年龄较小是眼压升高的一个具有统计学意义的预测因素（p = 0.009）。
在本研究中，需要进行滤过手术的患者在注射后一周内眼压急剧升高。因此，临床医生应考虑在第一周结束时检查眼压。此外，对于相对年轻的患者必须更加谨慎。
