Nanni G, Balduzzi G, Botta C, Capoluongo R, Demichelis P, Scansetti M, Silano E
Unit of General Surgery I, S. Andrea Hospital, ASL 11, Vercelli, Italy.
Minerva Gastroenterol Dietol. 2005 Jun;51(2):209-12.
Biliopancreatic diversion (BPD) has been accepted as an effective surgical treatment of morbid obesity. The paper presents the results of a personal clinical experience with this procedure, with special focus on the quality of life.
From January 1, 1992 to June 30, 2002, 122 patients (F/M: 108/14, mean age: 40.2 years, range 21-61) underwent BPD. Mean preoperative body weight was 122.4 kg (range 91-200), with a mean Body Mass Index of 49.1 kg/m2 (range 38-78). Three of these patients were converted from a previous vertical banded gastroplasty to BPD (1 patients with stomach preservation). After at least a 36-month follow-up, 10 patients underwent abdominal dermolipectomy (8 associated to incisional hernia repair, 1 associated to thigh dermolipectomy).
Mean postoperative hospital stay was 12 days (range: 11-30). Follow-up is currently in progress in all patients. Weight loss of initial overweight was 75% in 88 patients with a 36-month follow-up, with excellent long-term weight maintenance. Protein deficiency was the main specific complication, encountered in 6 patients (4.9%). Beneficial effects, other than those consequent to weight loss, included permanent normalization of serum cholesterol and glucose without any medication and on a totally free diet. Almost 80% of the patients reported an improvement in their self-esteem, physical activity, work condition and social life.
This clinical experience supports the effectiveness and safety of BPD, despite some criticism. The small number of side effects and complications, the excellent weight loss and the recovery of most co-morbidity leads to a great improvement in quality of life.
胆胰转流术(BPD)已被公认为是治疗病态肥胖的一种有效手术方法。本文介绍了个人对该手术的临床经验结果,特别关注生活质量。
1992年1月1日至2002年6月30日,122例患者(女/男:108/14,平均年龄:40.2岁,范围21 - 61岁)接受了BPD手术。术前平均体重为122.4千克(范围91 - 200),平均体重指数为49.1千克/平方米(范围38 - 78)。其中3例患者由先前的垂直束带胃成形术转为BPD(1例保留胃)。经过至少36个月的随访,10例患者接受了腹部皮肤切除术(8例与切口疝修补相关,1例与大腿皮肤切除术相关)。
术后平均住院时间为12天(范围:11 - 30天)。所有患者目前仍在随访中。88例接受36个月随访的患者,初始超重体重减轻了75%,长期体重维持良好。蛋白质缺乏是主要的特异性并发症,6例患者(4.9%)出现该并发症。除体重减轻带来的益处外,其他有益效果包括血清胆固醇和血糖在无需任何药物治疗且完全自由饮食的情况下永久恢复正常。近80%的患者报告自尊、身体活动、工作状况和社交生活有所改善。
尽管存在一些批评,但该临床经验支持BPD的有效性和安全性。副作用和并发症数量少,减肥效果极佳,大多数合并症得到缓解,导致生活质量大幅提高。