Kim DongHoon, Ko YoungHyeh, Suh Yeonlim, Koo HongHoe, Huh JooRyung, Lee WonKeun
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-gu, Ilwon-dong 50, 135-710 Seoul, South Korea.
Virchows Arch. 2005 Sep;447(3):593-6. doi: 10.1007/s00428-005-1277-4. Epub 2005 Jul 1.
To analyze the clinicopathologic characteristics of childhood non-Hodgkin's lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt's lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.
为分析与爱泼斯坦-巴尔病毒（EBV）相关的儿童非霍奇金淋巴瘤（NHL）的临床病理特征，对80例NHL进行了EBER原位杂交检测。EBER阳性淋巴瘤占25%（20/80），包括NK/T细胞淋巴瘤（6/6）、侵袭性NK细胞白血病（1/1）、外周T细胞淋巴瘤（5/11）、弥漫性大B细胞淋巴瘤（5/14）、水疱样T细胞淋巴瘤（1/1）、边缘区B细胞淋巴瘤（1/2）和移植后淋巴细胞增生性疾病（1/1）。其他类型包括19例伯基特淋巴瘤均为阴性。对9例EBER阳性病例进行了LMP-1和EBNA-2免疫组化染色以确定EBV潜伏模式。9例EBER阳性病例中有2例同时表达LMP-1和EBNA-2。临床上，EBV阳性B细胞淋巴瘤患者通过化疗治愈，而EBV相关的NK和T细胞淋巴瘤则呈致命临床病程。总之，儿童NHL中感染的EBV不仅常与NK和T细胞淋巴瘤相关，也与大B细胞淋巴瘤相关。
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