以被动妄想为特征的精神分裂症患者顶叶和额叶联合区体积减小。
Reduced volume of parietal and frontal association areas in patients with schizophrenia characterized by passivity delusions.
作者信息
Maruff P, Wood S J, Velakoulis D, Smith D J, Soulsby B, Suckling J, Bullmore E T, Pantelis C
机构信息
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Sunshine Hospital, St Albans, Melbourne, Australia.
出版信息
Psychol Med. 2005 Jun;35(6):783-9. doi: 10.1017/s0033291704003113.
BACKGROUND
In patients with schizophrenia, passivity delusions are characterized by a difficulty in determining the agency of purposive actions. Neuropsychological and functional neuroimaging data suggest that passivity delusions are associated with dysfunction of the parietal lobe association cortex.
METHOD
Cortical volume calculated from magnetic resonance imaging data in a group of 12 patients with schizophrenia characterized by motor passivity delusions was compared statistically with the cortical volume of 11 patients without passivity delusions.
RESULTS
Reduced cortical volume was observed in parietal and frontal association cortices in the passivity group.
CONCLUSIONS
These data provide direct evidence for the involvement of the parietal lobe in the pathophysiology of passivity delusions in schizophrenia.
背景
在精神分裂症患者中，被动妄想的特征是难以确定有目的行为的施动者。神经心理学和功能性神经影像学数据表明，被动妄想与顶叶联合皮质功能障碍有关。
方法
对一组以运动性被动妄想为特征的12例精神分裂症患者的磁共振成像数据计算出的皮质体积，与11例无被动妄想患者的皮质体积进行统计学比较。
结果
被动妄想组的顶叶和额叶联合皮质出现皮质体积减小。
结论
这些数据为顶叶参与精神分裂症被动妄想的病理生理学提供了直接证据。
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